caa a22 4500 605491623 CHVBK 20210128100511.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10147-015-0811-x doi (NATIONALLICENCE)springer-10.1007/s10147-015-0811-x Loss of ARID1A expression is associated with poor prognosis in patients with stage I/II clear cell carcinoma of the ovary [Elektronische Daten] [Hiroaki Itamochi, Nao Oumi, Tetsuro Oishi, Tadahiro Shoji, Hiroyuki Fujiwara, Toru Sugiyama, Mitsuaki Suzuki, Junzo Kigawa, Tasuku Harada] Abstract : Background: Recent studies have shown that somatic mutations in the AT-rich interactive domain 1A (SWI-like) gene (ARID1A) are the most common genetic changes in clear cell carcinoma of the ovary (CCC). A gene mutation of ARID1A was found in approximately half of CCC cases, and led to absence of the encoded protein and inactivation of the putative tumor suppressor. Here, we investigated whether ARID1A could be a prognostic biomarker for this disease. Methods: We analyzed the protein expression of ARID1A in CCC from 112 patients by immunohistochemical staining, and evaluated the association of these molecular parameters with clinical outcome. Results: The loss of ARID1A expression was found in 39% (44/112) of CCC, and was not associated with patient age, FIGO stage, and status of residual tumor. The 5-year survival rate for FIGO stage I or II patients with negative tumor expression of ARID1A was lower than those with positive tumor expression of ARID1A (74% vs 91%), but this difference was not observed in FIGO stage III or IV patients. Multivariable analysis revealed that ARID1A expression was an independent prognostic factor in FIGO stage I or II CCC patients. Conclusion: ARID1A may be a biomarker that is predictive of the outcome of FIGO stage I and II CCC. Japan Society of Clinical Oncology, 2015 Ovarian carcinoma nationallicence Clear cell nationallicence ARID1A nationallicence Biomarker nationallicence Itamochi Hiroaki Department of Obstetrics and Gynecology, Tottori University School of Medicine, 36-1 Nishicho, 683-8504, Yonago, Tottori, Japan aut Oumi Nao Department of Obstetrics and Gynecology, Tottori University School of Medicine, 36-1 Nishicho, 683-8504, Yonago, Tottori, Japan aut Oishi Tetsuro Department of Obstetrics and Gynecology, Tottori University School of Medicine, 36-1 Nishicho, 683-8504, Yonago, Tottori, Japan aut Shoji Tadahiro Department of Obstetrics and Gynecology, Iwate Medical University, 19-1 Uchimaru, 020-8505, Morioka, Iwate, Japan aut Fujiwara Hiroyuki Department of Obstetrics and Gynecology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Sugiyama Toru Department of Obstetrics and Gynecology, Iwate Medical University, 19-1 Uchimaru, 020-8505, Morioka, Iwate, Japan aut Suzuki Mitsuaki Department of Obstetrics and Gynecology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Kigawa Junzo Matsue City Hospital, 32-1 Noshira, 690-8509, Matsue, Shimane, Japan aut Harada Tasuku Department of Obstetrics and Gynecology, Tottori University School of Medicine, 36-1 Nishicho, 683-8504, Yonago, Tottori, Japan aut International Journal of Clinical Oncology Springer Japan 20/5(2015-10-01), 967-973 1341-9625 20:5<967 2015 20 10147 https://doi.org/10.1007/s10147-015-0811-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-015-0811-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Itamochi Hiroaki Department of Obstetrics and Gynecology, Tottori University School of Medicine, 36-1 Nishicho, 683-8504, Yonago, Tottori, Japan aut NATIONALLICENCE 700 1- Oumi Nao Department of Obstetrics and Gynecology, Tottori University School of Medicine, 36-1 Nishicho, 683-8504, Yonago, Tottori, Japan aut NATIONALLICENCE 700 1- Oishi Tetsuro Department of Obstetrics and Gynecology, Tottori University School of Medicine, 36-1 Nishicho, 683-8504, Yonago, Tottori, Japan aut NATIONALLICENCE 700 1- Shoji Tadahiro Department of Obstetrics and Gynecology, Iwate Medical University, 19-1 Uchimaru, 020-8505, Morioka, Iwate, Japan aut NATIONALLICENCE 700 1- Fujiwara Hiroyuki Department of Obstetrics and Gynecology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Sugiyama Toru Department of Obstetrics and Gynecology, Iwate Medical University, 19-1 Uchimaru, 020-8505, Morioka, Iwate, Japan aut NATIONALLICENCE 700 1- Suzuki Mitsuaki Department of Obstetrics and Gynecology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Kigawa Junzo Matsue City Hospital, 32-1 Noshira, 690-8509, Matsue, Shimane, Japan aut NATIONALLICENCE 700 1- Harada Tasuku Department of Obstetrics and Gynecology, Tottori University School of Medicine, 36-1 Nishicho, 683-8504, Yonago, Tottori, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/5(2015-10-01), 967-973 1341-9625 20:5<967 2015 20 10147