Oncological benefit of primary tumor resection with high tie lymph node dissection in unresectable colorectal cancer with synchronous peritoneal metastasis: a propensity score analysis of data from a multi-institute database
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| 008 | 210128e20151001xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10147-015-0815-6 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10147-015-0815-6 | ||
| 245 | 0 | 0 | |a Oncological benefit of primary tumor resection with high tie lymph node dissection in unresectable colorectal cancer with synchronous peritoneal metastasis: a propensity score analysis of data from a multi-institute database |h [Elektronische Daten] |c [Tomohisa Furuhata, Kenji Okita, Toshihiko Nishidate, Koichi Hirata, Hirofumi Ohnishi, Hirotoshi Kobayashi, Kenjiro Kotake, Kenichi Sugihara] |
| 520 | 3 | |a Background: Peritoneal metastasis is recognized as a predictor of poor prognosis in patients with colorectal cancer, and whether surgical intervention for peritoneal metastasis has any clinical benefit has remained controversial. The purposes of this study were to identify prognostic factors in cases of unresectable colorectal cancer with synchronous peritoneal metastasis and to clarify the impacts of primary tumor resection with high tie lymph node dissection. Methods: A multi-institutional retrospective analysis was conducted of 579 patients who underwent resection of the primary tumor for unresectable colorectal cancer with peritoneal metastasis between 1991 and 2007. For these 579 patients, clinicopathological variables were analyzed for prognostic significance using Cox proportional hazards model and propensity score analysis to mitigate the selection bias. Results: Multivariate analysis revealed hematogenous metastasis (p<0.001), histology of the tumor (p=0.006), postoperative chemotherapy (p<0.001), and lymph node dissection (p=0.001) as independent prognostic factors. In the propensity-matched cohort, patients treated with high tie lymph node dissection showed a significantly better overall survival than those with low tie lymph node dissection (median overall survival 13.0 vs. 11.5months; p=0.041). Conclusions: It is suggested that primary tumor resection with high tie lymph node dissection favorably affects survival, even in unresectable colorectal cancer with peritoneal metastasis. | |
| 540 | |a Japan Society of Clinical Oncology, 2015 | ||
| 690 | 7 | |a Colorectal cancer |2 nationallicence | |
| 690 | 7 | |a Peritoneal metastasis |2 nationallicence | |
| 690 | 7 | |a Lymph node dissection |2 nationallicence | |
| 690 | 7 | |a Propensity score analysis |2 nationallicence | |
| 700 | 1 | |a Furuhata |D Tomohisa |u Department of Nursing, Sapporo Medical University, South 1, West 17, Chuo-ku, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Okita |D Kenji |u Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Nishidate |D Toshihiko |u Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Hirata |D Koichi |u Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Ohnishi |D Hirofumi |u Department of Public Health, Sapporo Medical University, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Kobayashi |D Hirotoshi |u Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Kotake |D Kenjiro |u Department of Surgery, Tochigi Cancer Center, Utsunomiya, Japan |4 aut | |
| 700 | 1 | |a Sugihara |D Kenichi |u Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/5(2015-10-01), 922-927 |x 1341-9625 |q 20:5<922 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-015-0815-6 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-015-0815-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Furuhata |D Tomohisa |u Department of Nursing, Sapporo Medical University, South 1, West 17, Chuo-ku, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Okita |D Kenji |u Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nishidate |D Toshihiko |u Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hirata |D Koichi |u Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ohnishi |D Hirofumi |u Department of Public Health, Sapporo Medical University, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kobayashi |D Hirotoshi |u Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kotake |D Kenjiro |u Department of Surgery, Tochigi Cancer Center, Utsunomiya, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sugihara |D Kenichi |u Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/5(2015-10-01), 922-927 |x 1341-9625 |q 20:5<922 |1 2015 |2 20 |o 10147 | ||