caa a22 4500 605491631 CHVBK 20210128100511.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10147-015-0815-6 doi (NATIONALLICENCE)springer-10.1007/s10147-015-0815-6 Oncological benefit of primary tumor resection with high tie lymph node dissection in unresectable colorectal cancer with synchronous peritoneal metastasis: a propensity score analysis of data from a multi-institute database [Elektronische Daten] [Tomohisa Furuhata, Kenji Okita, Toshihiko Nishidate, Koichi Hirata, Hirofumi Ohnishi, Hirotoshi Kobayashi, Kenjiro Kotake, Kenichi Sugihara] Background: Peritoneal metastasis is recognized as a predictor of poor prognosis in patients with colorectal cancer, and whether surgical intervention for peritoneal metastasis has any clinical benefit has remained controversial. The purposes of this study were to identify prognostic factors in cases of unresectable colorectal cancer with synchronous peritoneal metastasis and to clarify the impacts of primary tumor resection with high tie lymph node dissection. Methods: A multi-institutional retrospective analysis was conducted of 579 patients who underwent resection of the primary tumor for unresectable colorectal cancer with peritoneal metastasis between 1991 and 2007. For these 579 patients, clinicopathological variables were analyzed for prognostic significance using Cox proportional hazards model and propensity score analysis to mitigate the selection bias. Results: Multivariate analysis revealed hematogenous metastasis (p<0.001), histology of the tumor (p=0.006), postoperative chemotherapy (p<0.001), and lymph node dissection (p=0.001) as independent prognostic factors. In the propensity-matched cohort, patients treated with high tie lymph node dissection showed a significantly better overall survival than those with low tie lymph node dissection (median overall survival 13.0 vs. 11.5months; p=0.041). Conclusions: It is suggested that primary tumor resection with high tie lymph node dissection favorably affects survival, even in unresectable colorectal cancer with peritoneal metastasis. Japan Society of Clinical Oncology, 2015 Colorectal cancer nationallicence Peritoneal metastasis nationallicence Lymph node dissection nationallicence Propensity score analysis nationallicence Furuhata Tomohisa Department of Nursing, Sapporo Medical University, South 1, West 17, Chuo-ku, Sapporo, Japan aut Okita Kenji Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan aut Nishidate Toshihiko Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan aut Hirata Koichi Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan aut Ohnishi Hirofumi Department of Public Health, Sapporo Medical University, Sapporo, Japan aut Kobayashi Hirotoshi Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan aut Kotake Kenjiro Department of Surgery, Tochigi Cancer Center, Utsunomiya, Japan aut Sugihara Kenichi Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan aut International Journal of Clinical Oncology Springer Japan 20/5(2015-10-01), 922-927 1341-9625 20:5<922 2015 20 10147 https://doi.org/10.1007/s10147-015-0815-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-015-0815-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Furuhata Tomohisa Department of Nursing, Sapporo Medical University, South 1, West 17, Chuo-ku, Sapporo, Japan aut NATIONALLICENCE 700 1- Okita Kenji Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan aut NATIONALLICENCE 700 1- Nishidate Toshihiko Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan aut NATIONALLICENCE 700 1- Hirata Koichi Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan aut NATIONALLICENCE 700 1- Ohnishi Hirofumi Department of Public Health, Sapporo Medical University, Sapporo, Japan aut NATIONALLICENCE 700 1- Kobayashi Hirotoshi Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan aut NATIONALLICENCE 700 1- Kotake Kenjiro Department of Surgery, Tochigi Cancer Center, Utsunomiya, Japan aut NATIONALLICENCE 700 1- Sugihara Kenichi Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/5(2015-10-01), 922-927 1341-9625 20:5<922 2015 20 10147