Treatment outcomes of external-beam radiotherapy for squamous cell carcinoma of the base of the tongue
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| 024 | 7 | 0 | |a 10.1007/s10147-015-0805-8 |2 doi |
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| 245 | 0 | 0 | |a Treatment outcomes of external-beam radiotherapy for squamous cell carcinoma of the base of the tongue |h [Elektronische Daten] |c [Yoshifumi Kawaguchi, Kinji Nishiyama, Takerou Hirata, Kouji Konishi, Shinji Otozai, Motoyuki Suzuki, Tadashi Yoshii, Takashi Fujii, Teruki Teshima] |
| 520 | 3 | |a Purpose: To evaluate definitive external-beam radiotherapy (EBRT) for patients with base of the tongue (BOT) cancers. Methods: We reviewed results for 26 patients with BOT cancers who were treated with EBRT. Clinical stages T1, T2, T3, and T4a were observed for 10, 7, 4, and 5 patients, respectively, and stages N0, N1, N2a, N2b, N2c, and N3 were observed for 4, 2, 5, 6, 8, and 1 patients, respectively. More than half of the patients (n=19) were stage IVA. Standard total delivered doses were 70Gy to primary tumors and cervical lymph node (CLN) metastases and 40-46Gy to elective nodal regions. Eleven patients with advanced loco-regional disease received concurrent or neoadjuvant chemotherapy. Four T3 patients and one T2 patient received 2 or 3 cycles of concurrent intra-arterial cisplatin with EBRT (RADPLAT). Results: Three-year overall survival was 69% (95% CI 47-83%), with a median follow-up period of 33months. Three-year local control was 100, 86, 100, and 20% for T1, T2, T3, and T4 patients, respectively. Three-year regional control was 100% for N0, N1, and N2a, 83% for N2b, 75% for N2c, and 0% for N3 patients. Treatment failed for 7 patients. All 5 patients undergoing RADPLAT achieved complete responses and did not develop local recurrence. Conclusions: We achieved favorable outcomes for patients with T1-T3 BOT cancers by use of definitive EBRT with or without chemotherapy. | |
| 540 | |a Japan Society of Clinical Oncology, 2015 | ||
| 690 | 7 | |a Base of tongue cancer |2 nationallicence | |
| 690 | 7 | |a External-beam radiotherapy |2 nationallicence | |
| 690 | 7 | |a Intra-arterial chemotherapy |2 nationallicence | |
| 690 | 7 | |a Organ preservation |2 nationallicence | |
| 700 | 1 | |a Kawaguchi |D Yoshifumi |u Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan |4 aut | |
| 700 | 1 | |a Nishiyama |D Kinji |u Department of Radiology, Yao Municipal Hospital, Osaka, Japan |4 aut | |
| 700 | 1 | |a Hirata |D Takerou |u Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan |4 aut | |
| 700 | 1 | |a Konishi |D Kouji |u Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan |4 aut | |
| 700 | 1 | |a Otozai |D Shinji |u Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan |4 aut | |
| 700 | 1 | |a Suzuki |D Motoyuki |u Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan |4 aut | |
| 700 | 1 | |a Yoshii |D Tadashi |u Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan |4 aut | |
| 700 | 1 | |a Fujii |D Takashi |u Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan |4 aut | |
| 700 | 1 | |a Teshima |D Teruki |u Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/5(2015-10-01), 891-896 |x 1341-9625 |q 20:5<891 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-015-0805-8 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-015-0805-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kawaguchi |D Yoshifumi |u Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nishiyama |D Kinji |u Department of Radiology, Yao Municipal Hospital, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hirata |D Takerou |u Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Konishi |D Kouji |u Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Otozai |D Shinji |u Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Suzuki |D Motoyuki |u Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yoshii |D Tadashi |u Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fujii |D Takashi |u Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Teshima |D Teruki |u Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/5(2015-10-01), 891-896 |x 1341-9625 |q 20:5<891 |1 2015 |2 20 |o 10147 | ||