caa a22 4500 60549164X CHVBK 20210128100511.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10147-015-0805-8 doi (NATIONALLICENCE)springer-10.1007/s10147-015-0805-8 Treatment outcomes of external-beam radiotherapy for squamous cell carcinoma of the base of the tongue [Elektronische Daten] [Yoshifumi Kawaguchi, Kinji Nishiyama, Takerou Hirata, Kouji Konishi, Shinji Otozai, Motoyuki Suzuki, Tadashi Yoshii, Takashi Fujii, Teruki Teshima] Purpose: To evaluate definitive external-beam radiotherapy (EBRT) for patients with base of the tongue (BOT) cancers. Methods: We reviewed results for 26 patients with BOT cancers who were treated with EBRT. Clinical stages T1, T2, T3, and T4a were observed for 10, 7, 4, and 5 patients, respectively, and stages N0, N1, N2a, N2b, N2c, and N3 were observed for 4, 2, 5, 6, 8, and 1 patients, respectively. More than half of the patients (n=19) were stage IVA. Standard total delivered doses were 70Gy to primary tumors and cervical lymph node (CLN) metastases and 40-46Gy to elective nodal regions. Eleven patients with advanced loco-regional disease received concurrent or neoadjuvant chemotherapy. Four T3 patients and one T2 patient received 2 or 3 cycles of concurrent intra-arterial cisplatin with EBRT (RADPLAT). Results: Three-year overall survival was 69% (95% CI 47-83%), with a median follow-up period of 33months. Three-year local control was 100, 86, 100, and 20% for T1, T2, T3, and T4 patients, respectively. Three-year regional control was 100% for N0, N1, and N2a, 83% for N2b, 75% for N2c, and 0% for N3 patients. Treatment failed for 7 patients. All 5 patients undergoing RADPLAT achieved complete responses and did not develop local recurrence. Conclusions: We achieved favorable outcomes for patients with T1-T3 BOT cancers by use of definitive EBRT with or without chemotherapy. Japan Society of Clinical Oncology, 2015 Base of tongue cancer nationallicence External-beam radiotherapy nationallicence Intra-arterial chemotherapy nationallicence Organ preservation nationallicence Kawaguchi Yoshifumi Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan aut Nishiyama Kinji Department of Radiology, Yao Municipal Hospital, Osaka, Japan aut Hirata Takerou Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan aut Konishi Kouji Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan aut Otozai Shinji Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut Suzuki Motoyuki Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut Yoshii Tadashi Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut Fujii Takashi Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut Teshima Teruki Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan aut International Journal of Clinical Oncology Springer Japan 20/5(2015-10-01), 891-896 1341-9625 20:5<891 2015 20 10147 https://doi.org/10.1007/s10147-015-0805-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-015-0805-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kawaguchi Yoshifumi Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan aut NATIONALLICENCE 700 1- Nishiyama Kinji Department of Radiology, Yao Municipal Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Hirata Takerou Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan aut NATIONALLICENCE 700 1- Konishi Kouji Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan aut NATIONALLICENCE 700 1- Otozai Shinji Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut NATIONALLICENCE 700 1- Suzuki Motoyuki Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut NATIONALLICENCE 700 1- Yoshii Tadashi Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut NATIONALLICENCE 700 1- Fujii Takashi Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut NATIONALLICENCE 700 1- Teshima Teruki Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, 537-8511, Osaka, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/5(2015-10-01), 891-896 1341-9625 20:5<891 2015 20 10147