HPV genotyping for triage of women with abnormal cervical cancer screening results: a multicenter prospective study
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| 024 | 7 | 0 | |a 10.1007/s10147-015-0789-4 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10147-015-0789-4 | ||
| 245 | 0 | 0 | |a HPV genotyping for triage of women with abnormal cervical cancer screening results: a multicenter prospective study |h [Elektronische Daten] |c [Yuko Nakamura, Koji Matsumoto, Toyomi Satoh, Ken Nishide, Akiko Nozue, Koji Shimabukuro, Seiichi Endo, Kimihiro Nagai, Akinori Oki, Hiroyuki Ochi, Yukio Morishita, Masayuki Noguchi, Hiroyuki Yoshikawa] |
| 520 | 3 | |a Background: In cervical cancer screening programs, women with abnormal cytology are referred for colposcopy for histological evaluation. We examined whether a human papillomavirus (HPV) genotyping assay could be used to identify women who do not need immediate colposcopy and biopsy because of low risk of cervical intraepithelial neoplasia grade 3 or worse (CIN3+). Methods: We prospectively evaluated test performance for 2 carcinogenic HPV genotypes (HPV16/18), for 8 types (HPV16/18/31/33/35/45/52/58), and for 13 types (HPV16/18/31/33/35/45/51/52/56/58/59/68) for prediction of histological CIN3+results among 427 screen-positive women referred for colposcopy. The study subjects consisted of 214 women with low-grade squamous intraepithelial lesion (LSIL), 184 with high-grade squamous intraepithelial lesion (HSIL), and 29 with atypical squamous cells, cannot exclude HSIL (ASC-H). Results: Among women with LSIL cytology, HPV16/18 positivity was 29.4% and increased to 58.9% for 8 types and to 74.8% for 13 types (P<0.001). The risk of CIN3+biopsy results was still 7.9% for women testing negative for HPV16/18, but decreased to 0.0% for those testing negative for at least eight types of HPV (HPV16/18/31/33/35/45/52/58). Although HPV genotyping results enabled additional risk stratification among women with HSIL/ASC-H cytology, the risk of histological CIN3+diagnosis among women testing negative for eight types or more was still sufficiently high (>35%) to warrant immediate colposcopy referral. Conclusions: Of women with LSIL cytology, those testing negative for at least eight of the highest-risk types of HPV (HPV16/18/31/33/35/45/52/58) may not need immediate colposcopy and biopsy. This would reduce the number of colposcopy referrals by approximately 40%. However, the HPV genotyping assay is not likely to alter the clinical management of women with HSIL/ASC-H. | |
| 540 | |a Japan Society of Clinical Oncology, 2015 | ||
| 690 | 7 | |a Human papillomavirus |2 nationallicence | |
| 690 | 7 | |a Genotyping |2 nationallicence | |
| 690 | 7 | |a Colposcopy |2 nationallicence | |
| 690 | 7 | |a Cervical intraepithelial neoplasia |2 nationallicence | |
| 690 | 7 | |a Cervical cancer |2 nationallicence | |
| 690 | 7 | |a Low-grade squamous intraepithelial lesion |2 nationallicence | |
| 700 | 1 | |a Nakamura |D Yuko |u Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | |
| 700 | 1 | |a Matsumoto |D Koji |u Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | |
| 700 | 1 | |a Satoh |D Toyomi |u Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | |
| 700 | 1 | |a Nishide |D Ken |u Department of Gynecology, Tsukuba Medical Center Hospital, 305-8558, Tsukuba, Japan |4 aut | |
| 700 | 1 | |a Nozue |D Akiko |u Department of Gynecology, Tsukuba Medical Center Hospital, 305-8558, Tsukuba, Japan |4 aut | |
| 700 | 1 | |a Shimabukuro |D Koji |u Department of Obstetrics and Gynecology, Tsuchiura Kyodo General Hospital, 300-0053, Tsuchiura, Japan |4 aut | |
| 700 | 1 | |a Endo |D Seiichi |u Department of Obstetrics and Gynecology, Tsuchiura Kyodo General Hospital, 300-0053, Tsuchiura, Japan |4 aut | |
| 700 | 1 | |a Nagai |D Kimihiro |u Department of Gynecology, Ibaraki Prefectural Central Hospital, 309-1793, Kasama, Japan |4 aut | |
| 700 | 1 | |a Oki |D Akinori |u Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | |
| 700 | 1 | |a Ochi |D Hiroyuki |u Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | |
| 700 | 1 | |a Morishita |D Yukio |u Department of Pathology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | |
| 700 | 1 | |a Noguchi |D Masayuki |u Department of Pathology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | |
| 700 | 1 | |a Yoshikawa |D Hiroyuki |u Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/5(2015-10-01), 974-981 |x 1341-9625 |q 20:5<974 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-015-0789-4 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-015-0789-4 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nakamura |D Yuko |u Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Matsumoto |D Koji |u Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Satoh |D Toyomi |u Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nishide |D Ken |u Department of Gynecology, Tsukuba Medical Center Hospital, 305-8558, Tsukuba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nozue |D Akiko |u Department of Gynecology, Tsukuba Medical Center Hospital, 305-8558, Tsukuba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shimabukuro |D Koji |u Department of Obstetrics and Gynecology, Tsuchiura Kyodo General Hospital, 300-0053, Tsuchiura, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Endo |D Seiichi |u Department of Obstetrics and Gynecology, Tsuchiura Kyodo General Hospital, 300-0053, Tsuchiura, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nagai |D Kimihiro |u Department of Gynecology, Ibaraki Prefectural Central Hospital, 309-1793, Kasama, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Oki |D Akinori |u Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ochi |D Hiroyuki |u Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Morishita |D Yukio |u Department of Pathology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Noguchi |D Masayuki |u Department of Pathology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yoshikawa |D Hiroyuki |u Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/5(2015-10-01), 974-981 |x 1341-9625 |q 20:5<974 |1 2015 |2 20 |o 10147 | ||