Impact of variant histology on disease aggressiveness and outcome after nephroureterectomy in Japanese patients with upper tract urothelial carcinoma
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| 024 | 7 | 0 | |a 10.1007/s10147-014-0721-3 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10147-014-0721-3 | ||
| 245 | 0 | 0 | |a Impact of variant histology on disease aggressiveness and outcome after nephroureterectomy in Japanese patients with upper tract urothelial carcinoma |h [Elektronische Daten] |c [Shigeru Sakano, Hideyasu Matsuyama, Yoriaki Kamiryo, Shigeaki Hayashida, Norio Yamamoto, Yoshitaka Kaneda, Takahito Nasu, Yoshikazu Baba, Tomoyuki Shimabukuro, Akinobu Suga, Mitsutaka Yamamoto, Akihiko Aoki, Kimio Takai, Satoru Yoshihiro, Kazuo Oba] |
| 520 | 3 | |a Abstract : Background: Patients with urinary bladder urothelial carcinoma (UC) with variant histology have features of more advanced disease and a likelihood of poorer survival than those with pure UC. We investigated the impact of variant histology on disease aggressiveness and clinical outcome after radical nephroureterectomy (RNU) in Japanese patients with upper tract UC (UTUC). Information on variant histology might guide appropriate patient selection for adjuvant therapy after RNU. Methods: We enrolled 502 UTUC patients treated with RNU in this retrospective cohort study, and analyzed associations of variant histology with clinicopathological variables and disease-specific survival. Results: The median follow-up was 41.4months. A total of 60 (12.0%) UTUC patients had variant histology. UTUC with variant histology was significantly associated with advanced pathological T stage (pT≥3), higher tumor grade (G3), and more lymphovascular invasion (P<0.0001). Variant histology in all patients was significantly associated with worse disease-specific survival after RNU on univariate analysis (P=0.0004), but this effect did not remain significant on multivariate analysis. However, variant histology was a significantly independent predictor for disease-specific survival in patients with pT≥3 tumors (P=0.0095). Conclusions: UTUC with variant histology might be a phenotype of high-grade, locally aggressive advanced tumors rather than of systemic disease. Variant histology may be useful for selection of patients with pT≥3 UTUC for adjuvant therapy. Prospective studies in a larger number of patients with a centralized pathological review are needed to confirm our results. | |
| 540 | |a Japan Society of Clinical Oncology, 2014 | ||
| 690 | 7 | |a Histology |2 nationallicence | |
| 690 | 7 | |a Kidney pelvis |2 nationallicence | |
| 690 | 7 | |a Survival |2 nationallicence | |
| 690 | 7 | |a Transitional cell carcinoma |2 nationallicence | |
| 690 | 7 | |a Ureteral neoplasms |2 nationallicence | |
| 700 | 1 | |a Sakano |D Shigeru |u Department of Urology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, 755-8505, Ube, Yamaguchi, Japan |4 aut | |
| 700 | 1 | |a Matsuyama |D Hideyasu |u Department of Urology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, 755-8505, Ube, Yamaguchi, Japan |4 aut | |
| 700 | 1 | |a Kamiryo |D Yoriaki |u Department of Urology, Shimonoseki Municipal Saiseikai Toyoura Hospital, 7-3 Kogushi, Toyoura, 759-6302, Shimonoseki, Yamaguchi, Japan |4 aut | |
| 700 | 1 | |a Hayashida |D Shigeaki |u Department of Urology and Nephrology, Tokuyama Central Hospital, 1-1 Takada, 745-8522, Shunan, Yamaguchi, Japan |4 aut | |
| 700 | 1 | |a Yamamoto |D Norio |u Department of Urology, Tokuyama Medical Association Hospital, 6-28 Higashiyama, 745-0846, Shunan, Yamaguchi, Japan |4 aut | |
| 700 | 1 | |a Kaneda |D Yoshitaka |u Department of Urology, Konan St. Hill Hospital, 108 Tsumasakikaisaku, 759-0204, Ube, Yamaguchi, Japan |4 aut | |
| 700 | 1 | |a Nasu |D Takahito |u Department of Urology and Nephrology, Tokuyama Central Hospital, 1-1 Takada, 745-8522, Shunan, Yamaguchi, Japan |4 aut | |
| 700 | 1 | |a Baba |D Yoshikazu |u Department of Urology, Shuto General Hospital, 1000-1 Kokaisaku, 742-0032, Yanai, Yamaguchi, Japan |4 aut | |
| 700 | 1 | |a Shimabukuro |D Tomoyuki |u Department of Urology, Ube Industries Central Hospital, 750 Nishikiwa, 755-0151, Ube, Yamaguchi, Japan |4 aut | |
| 700 | 1 | |a Suga |D Akinobu |u Department of Urology, Yamaguchi Red Cross Hospital, 53-1 Hachimanbaba Yamaguchi, 753-8519, Yamaguchi, Japan |4 aut | |
| 700 | 1 | |a Yamamoto |D Mitsutaka |u Department of Urology, Yamaguchi Grand Medical Center, 77 Ohsaki, 747-8511, Hofu, Yamaguchi, Japan |4 aut | |
| 700 | 1 | |a Aoki |D Akihiko |u Department of Urology, Masuda Red Cross Hospital, I 103-1 Otoyoshi, Masuda, 698-8501, Shimane, Japan |4 aut | |
| 700 | 1 | |a Takai |D Kimio |u Department of Urology, Saiseikai Shimonoseki General Hospital, 8-5-1 Yasuoka, 759-6603, Shimonoseki, Yamaguchi, Japan |4 aut | |
| 700 | 1 | |a Yoshihiro |D Satoru |u Department of Urology, Shimonoseki City Hospital, 1-13-1 Koyo, 750-8520, Shimonoseki, Yamaguchi, Japan |4 aut | |
| 700 | 1 | |a Oba |D Kazuo |u Department of Urology, Saiseikai Yamaguchi General Hospital, 2-11 Midorimachi, Yamaguchi, 753-0078, Yamaguchi, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/2(2015-04-01), 362-368 |x 1341-9625 |q 20:2<362 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-014-0721-3 |q text/html |z Onlinezugriff via DOI |
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| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-014-0721-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sakano |D Shigeru |u Department of Urology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, 755-8505, Ube, Yamaguchi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Matsuyama |D Hideyasu |u Department of Urology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, 755-8505, Ube, Yamaguchi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kamiryo |D Yoriaki |u Department of Urology, Shimonoseki Municipal Saiseikai Toyoura Hospital, 7-3 Kogushi, Toyoura, 759-6302, Shimonoseki, Yamaguchi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hayashida |D Shigeaki |u Department of Urology and Nephrology, Tokuyama Central Hospital, 1-1 Takada, 745-8522, Shunan, Yamaguchi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yamamoto |D Norio |u Department of Urology, Tokuyama Medical Association Hospital, 6-28 Higashiyama, 745-0846, Shunan, Yamaguchi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kaneda |D Yoshitaka |u Department of Urology, Konan St. Hill Hospital, 108 Tsumasakikaisaku, 759-0204, Ube, Yamaguchi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nasu |D Takahito |u Department of Urology and Nephrology, Tokuyama Central Hospital, 1-1 Takada, 745-8522, Shunan, Yamaguchi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Baba |D Yoshikazu |u Department of Urology, Shuto General Hospital, 1000-1 Kokaisaku, 742-0032, Yanai, Yamaguchi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shimabukuro |D Tomoyuki |u Department of Urology, Ube Industries Central Hospital, 750 Nishikiwa, 755-0151, Ube, Yamaguchi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Suga |D Akinobu |u Department of Urology, Yamaguchi Red Cross Hospital, 53-1 Hachimanbaba Yamaguchi, 753-8519, Yamaguchi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yamamoto |D Mitsutaka |u Department of Urology, Yamaguchi Grand Medical Center, 77 Ohsaki, 747-8511, Hofu, Yamaguchi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Aoki |D Akihiko |u Department of Urology, Masuda Red Cross Hospital, I 103-1 Otoyoshi, Masuda, 698-8501, Shimane, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Takai |D Kimio |u Department of Urology, Saiseikai Shimonoseki General Hospital, 8-5-1 Yasuoka, 759-6603, Shimonoseki, Yamaguchi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yoshihiro |D Satoru |u Department of Urology, Shimonoseki City Hospital, 1-13-1 Koyo, 750-8520, Shimonoseki, Yamaguchi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Oba |D Kazuo |u Department of Urology, Saiseikai Yamaguchi General Hospital, 2-11 Midorimachi, Yamaguchi, 753-0078, Yamaguchi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/2(2015-04-01), 362-368 |x 1341-9625 |q 20:2<362 |1 2015 |2 20 |o 10147 | ||