caa a22 4500 605491704 CHVBK 20210128100511.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10147-014-0721-3 doi (NATIONALLICENCE)springer-10.1007/s10147-014-0721-3 Impact of variant histology on disease aggressiveness and outcome after nephroureterectomy in Japanese patients with upper tract urothelial carcinoma [Elektronische Daten] [Shigeru Sakano, Hideyasu Matsuyama, Yoriaki Kamiryo, Shigeaki Hayashida, Norio Yamamoto, Yoshitaka Kaneda, Takahito Nasu, Yoshikazu Baba, Tomoyuki Shimabukuro, Akinobu Suga, Mitsutaka Yamamoto, Akihiko Aoki, Kimio Takai, Satoru Yoshihiro, Kazuo Oba] Abstract : Background: Patients with urinary bladder urothelial carcinoma (UC) with variant histology have features of more advanced disease and a likelihood of poorer survival than those with pure UC. We investigated the impact of variant histology on disease aggressiveness and clinical outcome after radical nephroureterectomy (RNU) in Japanese patients with upper tract UC (UTUC). Information on variant histology might guide appropriate patient selection for adjuvant therapy after RNU. Methods: We enrolled 502 UTUC patients treated with RNU in this retrospective cohort study, and analyzed associations of variant histology with clinicopathological variables and disease-specific survival. Results: The median follow-up was 41.4months. A total of 60 (12.0%) UTUC patients had variant histology. UTUC with variant histology was significantly associated with advanced pathological T stage (pT≥3), higher tumor grade (G3), and more lymphovascular invasion (P<0.0001). Variant histology in all patients was significantly associated with worse disease-specific survival after RNU on univariate analysis (P=0.0004), but this effect did not remain significant on multivariate analysis. However, variant histology was a significantly independent predictor for disease-specific survival in patients with pT≥3 tumors (P=0.0095). Conclusions: UTUC with variant histology might be a phenotype of high-grade, locally aggressive advanced tumors rather than of systemic disease. Variant histology may be useful for selection of patients with pT≥3 UTUC for adjuvant therapy. Prospective studies in a larger number of patients with a centralized pathological review are needed to confirm our results. Japan Society of Clinical Oncology, 2014 Histology nationallicence Kidney pelvis nationallicence Survival nationallicence Transitional cell carcinoma nationallicence Ureteral neoplasms nationallicence Sakano Shigeru Department of Urology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, 755-8505, Ube, Yamaguchi, Japan aut Matsuyama Hideyasu Department of Urology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, 755-8505, Ube, Yamaguchi, Japan aut Kamiryo Yoriaki Department of Urology, Shimonoseki Municipal Saiseikai Toyoura Hospital, 7-3 Kogushi, Toyoura, 759-6302, Shimonoseki, Yamaguchi, Japan aut Hayashida Shigeaki Department of Urology and Nephrology, Tokuyama Central Hospital, 1-1 Takada, 745-8522, Shunan, Yamaguchi, Japan aut Yamamoto Norio Department of Urology, Tokuyama Medical Association Hospital, 6-28 Higashiyama, 745-0846, Shunan, Yamaguchi, Japan aut Kaneda Yoshitaka Department of Urology, Konan St. Hill Hospital, 108 Tsumasakikaisaku, 759-0204, Ube, Yamaguchi, Japan aut Nasu Takahito Department of Urology and Nephrology, Tokuyama Central Hospital, 1-1 Takada, 745-8522, Shunan, Yamaguchi, Japan aut Baba Yoshikazu Department of Urology, Shuto General Hospital, 1000-1 Kokaisaku, 742-0032, Yanai, Yamaguchi, Japan aut Shimabukuro Tomoyuki Department of Urology, Ube Industries Central Hospital, 750 Nishikiwa, 755-0151, Ube, Yamaguchi, Japan aut Suga Akinobu Department of Urology, Yamaguchi Red Cross Hospital, 53-1 Hachimanbaba Yamaguchi, 753-8519, Yamaguchi, Japan aut Yamamoto Mitsutaka Department of Urology, Yamaguchi Grand Medical Center, 77 Ohsaki, 747-8511, Hofu, Yamaguchi, Japan aut Aoki Akihiko Department of Urology, Masuda Red Cross Hospital, I 103-1 Otoyoshi, Masuda, 698-8501, Shimane, Japan aut Takai Kimio Department of Urology, Saiseikai Shimonoseki General Hospital, 8-5-1 Yasuoka, 759-6603, Shimonoseki, Yamaguchi, Japan aut Yoshihiro Satoru Department of Urology, Shimonoseki City Hospital, 1-13-1 Koyo, 750-8520, Shimonoseki, Yamaguchi, Japan aut Oba Kazuo Department of Urology, Saiseikai Yamaguchi General Hospital, 2-11 Midorimachi, Yamaguchi, 753-0078, Yamaguchi, Japan aut International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 362-368 1341-9625 20:2<362 2015 20 10147 https://doi.org/10.1007/s10147-014-0721-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0721-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sakano Shigeru Department of Urology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Matsuyama Hideyasu Department of Urology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Kamiryo Yoriaki Department of Urology, Shimonoseki Municipal Saiseikai Toyoura Hospital, 7-3 Kogushi, Toyoura, 759-6302, Shimonoseki, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Hayashida Shigeaki Department of Urology and Nephrology, Tokuyama Central Hospital, 1-1 Takada, 745-8522, Shunan, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Yamamoto Norio Department of Urology, Tokuyama Medical Association Hospital, 6-28 Higashiyama, 745-0846, Shunan, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Kaneda Yoshitaka Department of Urology, Konan St. Hill Hospital, 108 Tsumasakikaisaku, 759-0204, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Nasu Takahito Department of Urology and Nephrology, Tokuyama Central Hospital, 1-1 Takada, 745-8522, Shunan, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Baba Yoshikazu Department of Urology, Shuto General Hospital, 1000-1 Kokaisaku, 742-0032, Yanai, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Shimabukuro Tomoyuki Department of Urology, Ube Industries Central Hospital, 750 Nishikiwa, 755-0151, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Suga Akinobu Department of Urology, Yamaguchi Red Cross Hospital, 53-1 Hachimanbaba Yamaguchi, 753-8519, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Yamamoto Mitsutaka Department of Urology, Yamaguchi Grand Medical Center, 77 Ohsaki, 747-8511, Hofu, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Aoki Akihiko Department of Urology, Masuda Red Cross Hospital, I 103-1 Otoyoshi, Masuda, 698-8501, Shimane, Japan aut NATIONALLICENCE 700 1- Takai Kimio Department of Urology, Saiseikai Shimonoseki General Hospital, 8-5-1 Yasuoka, 759-6603, Shimonoseki, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Yoshihiro Satoru Department of Urology, Shimonoseki City Hospital, 1-13-1 Koyo, 750-8520, Shimonoseki, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Oba Kazuo Department of Urology, Saiseikai Yamaguchi General Hospital, 2-11 Midorimachi, Yamaguchi, 753-0078, Yamaguchi, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 362-368 1341-9625 20:2<362 2015 20 10147