caa a22 4500 605491712 CHVBK 20210128100511.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10147-014-0722-2 doi (NATIONALLICENCE)springer-10.1007/s10147-014-0722-2 Hypersensitivity to chemotherapeutics: a cross sectional study with 35 desensitisations [Elektronische Daten] [Ozlem Goksel, Tuncay Goksel, Gursel Cok, Haydar Karakus, Feza Bacakoglu, Erdem Goker, Ruchan Uslu, Munevver Erdinc] Background: Chemotherapy is one of the main treatments for lung cancer, and in these patients, discontinuation of treatment due to uncontrollable hypersensitivity reactions (HSRs) is an important problem. Aim: To determine the frequency of HSRs during chemotherapy and to review current approaches. Methods: We did a cross sectional study in patients undergoing chemotherapy for lung cancer in a reference chemotherapy unit from January 2012 to January 2013. Patients who developed immediate-HSRs or delayed-HSRs to chemotherapeutics and gave consent were included into study. The effectiveness of a standardised 12-step "rapid drug desensitisation” (RDD) procedure was investigated in patients with immediate-HSRs. Results: In total, 1,099 cycles of chemotherapy were administered to 292 patients in 1year. We observed ten HSRs, during ten cycles in ten patients (~3% of the patients). Two HSRs were delayed-type, eight were immediate-type at grade 1-3. Of those with immediate-type HSR, five patients with grade 2-3, and additional two referred patients with grade 4 HSRs were successfully given their culprit drug in 35 cycles of chemotherapy with 12-step or modified 20-step RDD protocol. Conclusions: HSRs to chemotherapeutics are not so rare. Premedication alone does not prevent such reactions. The results of RDD treatment look promising for continuing treatment with the culprit chemotherapeutic agent. Japan Society of Clinical Oncology, 2014 Lung cancer nationallicence Chemotherapeutics nationallicence Hypersensitivity nationallicence Rapid drug desensitisation nationallicence HSR : Hypersensitivity reaction nationallicence SIR : Standard infusion reaction nationallicence RDD : Rapid drug desensitisation nationallicence SPT : Skin prick test nationallicence Goksel Ozlem Department of Chest Diseases, Ege University Medical School, Izmir, Turkey aut Goksel Tuncay Department of Chest Diseases, Ege University Medical School, Izmir, Turkey aut Cok Gursel Department of Chest Diseases, Ege University Medical School, Izmir, Turkey aut Karakus Haydar Department of Chest Diseases, Ege University Medical School, Izmir, Turkey aut Bacakoglu Feza Department of Chest Diseases, Ege University Medical School, Izmir, Turkey aut Goker Erdem Department of Medical Oncology, Ege University Medical School, Izmir, Turkey aut Uslu Ruchan Department of Medical Oncology, Ege University Medical School, Izmir, Turkey aut Erdinc Munevver Department of Chest Diseases, Ege University Medical School, Izmir, Turkey aut International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 395-404 1341-9625 20:2<395 2015 20 10147 https://doi.org/10.1007/s10147-014-0722-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0722-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goksel Ozlem Department of Chest Diseases, Ege University Medical School, Izmir, Turkey aut NATIONALLICENCE 700 1- Goksel Tuncay Department of Chest Diseases, Ege University Medical School, Izmir, Turkey aut NATIONALLICENCE 700 1- Cok Gursel Department of Chest Diseases, Ege University Medical School, Izmir, Turkey aut NATIONALLICENCE 700 1- Karakus Haydar Department of Chest Diseases, Ege University Medical School, Izmir, Turkey aut NATIONALLICENCE 700 1- Bacakoglu Feza Department of Chest Diseases, Ege University Medical School, Izmir, Turkey aut NATIONALLICENCE 700 1- Goker Erdem Department of Medical Oncology, Ege University Medical School, Izmir, Turkey aut NATIONALLICENCE 700 1- Uslu Ruchan Department of Medical Oncology, Ege University Medical School, Izmir, Turkey aut NATIONALLICENCE 700 1- Erdinc Munevver Department of Chest Diseases, Ege University Medical School, Izmir, Turkey aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 395-404 1341-9625 20:2<395 2015 20 10147