caa a22 4500 605491771 CHVBK 20210128100511.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10147-014-0702-6 doi (NATIONALLICENCE)springer-10.1007/s10147-014-0702-6 Analysis of prognostic factors for patients with bulky squamous cell carcinoma of the uterine cervix who underwent neoadjuvant chemotherapy followed by radical hysterectomy [Elektronische Daten] [Eriko Takatori, Tadahiro Shoji, Hideo Omi, Masahiro Kagabu, Fumiharu Miura, Satoshi Takeuchi, Seisuke Kumagai, Akira Yoshizaki, Akira Sato, Toru Sugiyama] Background: Neoadjuvant chemotherapy (NAC) is not yet widely recommended for the treatment of stage I/II cervical cancer. However, it may be possible to achieve a favorable outcome by selecting appropriate patients. In the present study, prognostic factors were retrospectively investigated to obtain data for devising individualized NAC. Patients and methods: The subjects were 33 patients with bulky stage Ib2-IIb squamous cell carcinoma (SCC) of the uterine cervix who gave consent and were scheduled to undergo radical hysterectomy. The patients intravenously received irinotecan 70mg/m2 on days 1 and 8 and cisplatin 70mg/m2 on day 1 of a 21-day course, and two courses were performed in principle. The potential prognostic factors investigated were age, performance status (PS), clinical stage, lymph node metastasis and tumor size before NAC, SCC antigen value, anti-tumor response, histological effect of NAC, lymph node metastasis in resected specimens, and postoperative adjuvant therapy after NAC. The impacts of these factors on overall survival (OS) were calculated with the Cox regression model. Results: According to the univariate analysis, lymph node metastasis before NAC, SCC antigen value after NAC, anti-tumor response, and histological effect of NAC significantly influenced OS. These factors were tested in a multivariate model, and significant prognostic factors were lymph node metastasis before NAC (hazard ratio 0.116, P=0.027) and anti-tumor response (hazard ratio 0.025, P=0.003). Conclusion: The presence or absence of lymph node metastasis by computed tomography imaging was the only significant prognostic factor identified during the pre-NAC period. Japan Society of Clinical Oncology, 2014 Prognostic analysis nationallicence Cervical cancer nationallicence Bulky tumor nationallicence Squamous cell carcinoma nationallicence Neoadjuvant chemotherapy nationallicence Takatori Eriko Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut Shoji Tadahiro Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut Omi Hideo Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut Kagabu Masahiro Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut Miura Fumiharu Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut Takeuchi Satoshi Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut Kumagai Seisuke Department of Obstetrics and Gynecology, National Hospital Organization Kokura Medical Center, Kokura, Japan aut Yoshizaki Akira Department of Gynecology, Miyama Hospital, Oshu, Japan aut Sato Akira Department of Gynecology, Medical Coat Hachinohe West Hospital, Hachinohe, Japan aut Sugiyama Toru Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 345-350 1341-9625 20:2<345 2015 20 10147 https://doi.org/10.1007/s10147-014-0702-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0702-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takatori Eriko Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut NATIONALLICENCE 700 1- Shoji Tadahiro Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut NATIONALLICENCE 700 1- Omi Hideo Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut NATIONALLICENCE 700 1- Kagabu Masahiro Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut NATIONALLICENCE 700 1- Miura Fumiharu Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut NATIONALLICENCE 700 1- Takeuchi Satoshi Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut NATIONALLICENCE 700 1- Kumagai Seisuke Department of Obstetrics and Gynecology, National Hospital Organization Kokura Medical Center, Kokura, Japan aut NATIONALLICENCE 700 1- Yoshizaki Akira Department of Gynecology, Miyama Hospital, Oshu, Japan aut NATIONALLICENCE 700 1- Sato Akira Department of Gynecology, Medical Coat Hachinohe West Hospital, Hachinohe, Japan aut NATIONALLICENCE 700 1- Sugiyama Toru Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 345-350 1341-9625 20:2<345 2015 20 10147