caa a22 4500 60549178X CHVBK 20210128100511.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10147-014-0703-5 doi (NATIONALLICENCE)springer-10.1007/s10147-014-0703-5 Administration of chemotherapy via the median cubital vein without implantable central venous access ports: port-free chemotherapy for metastatic colorectal cancer patients [Elektronische Daten] [Yoichiro Yoshida, Seiichiro Hoshino, Naoya Aisu, Masayasu Naito, Syu Tanimura, Ai Mogi, Toshihiro Tanaka, Keiji Hirata, Kazuo Tamura, Yuichi Yamashita] Background: Repeated venous punctures are usually required during chemotherapy administration for cancer patients. Central venous catheters and implantable port systems have substantially facilitated vascular access, and safe, easy-to-handle port systems have become an integral part of daily clinical routines in oncology. However, several serious complications are associated with central venous ports (CV-ports), and recent developments of combined oral capecitabine and oxaliplatin (XELOX) therapies allow CV-port-free administration. In this study, the safety and efficacy of CV-port-free chemotherapy administration via the median cubital vein was assessed in metastatic colorectal cancer patients. Methods: This study included 144 patients who received XELOX+bevacizumab (BV) or XELOX therapy for metastatic colorectal cancer without CV-port implantation. Results: Eighty-five patients experienced transient vascular pain. The drip infusion route was switched to the opposite side following vascular pain in only 1 patient. No patients required CV-port implantation or delayed treatment due to adverse events associated with drug administration via the peripheral vein. Grade 3 or higher hemotoxicity and grade 3 or higher non-hematological toxicity was noted in 12.5 and 17.4% of patients, respectively. Conclusions: Port-free-chemotherapy administration via the median cubital vein is appropriate for patients with colorectal cancer, thereby avoiding complications associated with CV-ports. Japan Society of Clinical Oncology, 2014 Chemotherapy nationallicence Colorectal cancer nationallicence Central venous port nationallicence Median cubital vein nationallicence Yoshida Yoichiro Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut Hoshino Seiichiro Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut Aisu Naoya Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut Naito Masayasu Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut Tanimura Syu Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut Mogi Ai Division of Oncology, Hematology and Infectious Diseases, Department of Internal Medicine, Fukuoka University Faculty of Medicine, Fukuoka, Japan aut Tanaka Toshihiro Division of Oncology, Hematology and Infectious Diseases, Department of Internal Medicine, Fukuoka University Faculty of Medicine, Fukuoka, Japan aut Hirata Keiji Department of Surgery, Fukuoka Sanno Hospital, Fukuoka, Japan aut Tamura Kazuo Division of Oncology, Hematology and Infectious Diseases, Department of Internal Medicine, Fukuoka University Faculty of Medicine, Fukuoka, Japan aut Yamashita Yuichi Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 332-337 1341-9625 20:2<332 2015 20 10147 https://doi.org/10.1007/s10147-014-0703-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0703-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoshida Yoichiro Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Hoshino Seiichiro Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Aisu Naoya Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Naito Masayasu Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Tanimura Syu Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Mogi Ai Division of Oncology, Hematology and Infectious Diseases, Department of Internal Medicine, Fukuoka University Faculty of Medicine, Fukuoka, Japan aut NATIONALLICENCE 700 1- Tanaka Toshihiro Division of Oncology, Hematology and Infectious Diseases, Department of Internal Medicine, Fukuoka University Faculty of Medicine, Fukuoka, Japan aut NATIONALLICENCE 700 1- Hirata Keiji Department of Surgery, Fukuoka Sanno Hospital, Fukuoka, Japan aut NATIONALLICENCE 700 1- Tamura Kazuo Division of Oncology, Hematology and Infectious Diseases, Department of Internal Medicine, Fukuoka University Faculty of Medicine, Fukuoka, Japan aut NATIONALLICENCE 700 1- Yamashita Yuichi Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 332-337 1341-9625 20:2<332 2015 20 10147