caa a22 4500 605491801 CHVBK 20210128100511.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10147-014-0710-6 doi (NATIONALLICENCE)springer-10.1007/s10147-014-0710-6 Combination of MUC1 and MUC4 expression predicts clinical outcome in patients with oral squamous cell carcinoma [Elektronische Daten] [Yoshiaki Kamikawa, Yuji Kanmura, Tomofumi Hamada, Norishige Yamada, Muzafar Macha, Surinder Batra, Michiyo Higashi, Suguru Yonezawa, Kazumasa Sugihara] Background: Both MUC1 and MUC4 are high molecular weight glycoproteins and are independent indicators of worse prognosis in many human epithelial cancers including oral squamous cell carcinoma (OSCC). However, there has been no investigation of the clinical importance of the co-expression of MUC1 and MUC4 in OSCC. The aim of this study was to evaluate the co-expression profile of MUC1/MUC4 and analyze the prognostic significance in OSCC. Methods: We examined the expression profile of MUC1 and MUC4 in OSCC tissues from 206 patients using immunohistochemistry. The co-expression profile of MUC1/MUC4 and its prognostic significance in OSCC was statistically analyzed. Results: MUC1 and MUC4 overexpression were strongly correlated with each other (p<0.0001) and a combination of both MUC1 and MUC4 expression was a powerful indicator for tumor aggressiveness such as tumor size (p=0.014), lymph node metastasis (0.0001), tumor stage (p=0.006), diffuse invasion (p=0.028), and vascular invasion (p=0.014). The MUC1/MUC4 double-positive patients showed the poorest overall and disease-free survival. Multivariate analysis revealed that MUC1/MUC4 double-positivity was the strong independent prognostic factor for overall and disease-free survival (p=0.007 and (p=0.0019), in addition to regional recurrence (p=0.0025). Conclusions: Taken together, these observations indicate that the use of a combination of MUC1/MUC4 can predict outcomes for patients with OSCC. This combination is also a useful marker for predicting regional recurrence. MUC1 and MUC4 may be attractive targets for the selection of treatment methods in OSCC. Japan Society of Clinical Oncology, 2014 Oral squamous cell carcinoma nationallicence MUC1 nationallicence MUC4 nationallicence Immunohistochemistry nationallicence Prognosis nationallicence Kamikawa Yoshiaki Department of Oral Surgery, Kagoshima University Hospital, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut Kanmura Yuji Department of Maxillofacial Diagnostic and Surgical Science, Field of Oral and Maxillofacial Rehabilitation, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut Hamada Tomofumi Department of Oral Surgery, Kagoshima University Hospital, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut Yamada Norishige Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, 45229, Ohio, USA aut Macha Muzafar Department of Biochemistry and Molecular Biology, Buffett Cancer Center, Eppley Cancer Institute, University of Nebraska Medical Center, 985870 Nebraska Medical Center, 68198-5870, Omaha, NE, USA aut Batra Surinder Department of Biochemistry and Molecular Biology, Buffett Cancer Center, Eppley Cancer Institute, University of Nebraska Medical Center, 985870 Nebraska Medical Center, 68198-5870, Omaha, NE, USA aut Higashi Michiyo Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut Yonezawa Suguru Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut Sugihara Kazumasa Department of Oral Surgery, Kagoshima University Hospital, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 298-307 1341-9625 20:2<298 2015 20 10147 https://doi.org/10.1007/s10147-014-0710-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0710-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kamikawa Yoshiaki Department of Oral Surgery, Kagoshima University Hospital, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 700 1- Kanmura Yuji Department of Maxillofacial Diagnostic and Surgical Science, Field of Oral and Maxillofacial Rehabilitation, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 700 1- Hamada Tomofumi Department of Oral Surgery, Kagoshima University Hospital, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 700 1- Yamada Norishige Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, 45229, Ohio, USA aut NATIONALLICENCE 700 1- Macha Muzafar Department of Biochemistry and Molecular Biology, Buffett Cancer Center, Eppley Cancer Institute, University of Nebraska Medical Center, 985870 Nebraska Medical Center, 68198-5870, Omaha, NE, USA aut NATIONALLICENCE 700 1- Batra Surinder Department of Biochemistry and Molecular Biology, Buffett Cancer Center, Eppley Cancer Institute, University of Nebraska Medical Center, 985870 Nebraska Medical Center, 68198-5870, Omaha, NE, USA aut NATIONALLICENCE 700 1- Higashi Michiyo Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 700 1- Yonezawa Suguru Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 700 1- Sugihara Kazumasa Department of Oral Surgery, Kagoshima University Hospital, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 298-307 1341-9625 20:2<298 2015 20 10147