[18F]fluoro-2-deoxyglucose-positron emission tomography for the assessment of histopathological response after preoperative chemoradiotherapy in advanced oral squamous cell carcinoma
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| 024 | 7 | 0 | |a 10.1007/s10147-014-0711-5 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10147-014-0711-5 | ||
| 245 | 0 | 0 | |a [18F]fluoro-2-deoxyglucose-positron emission tomography for the assessment of histopathological response after preoperative chemoradiotherapy in advanced oral squamous cell carcinoma |h [Elektronische Daten] |c [Hiroyuki Shimomura, Tomonori Sasahira, Yasutsugu Yamanaka, Miyako Kurihara, Yuichiro Imai, Shigehiro Tamaki, Nobuhiro Yamakawa, Norihisa Shirone, Masatoshi Hasegawa, Hiroki Kuniyasu, Tadaaki Kirita] |
| 520 | 3 | |a Background: [18F]fluoro-2-deoxyglucose-positron emission tomography (FDG-PET) is widely used to evaluate tumor metabolic activity. The aim of this study was to evaluate the usefulness of FDG-PET in assessing the histopathological response to preoperative concurrent chemoradiotherapy (CRT) in patients with oral squamous cell carcinoma (OSCC). Methods: Forty-five patients with resectable advanced OSCC who had received preoperative CRT followed by tumor ablative surgery between January 2004 and December 2011 were included in the study. All patients underwent FDG-PET before and after preoperative CRT. The maximum standardized uptake value (SUVmax) before (pre-SUV) and after preoperative CRT (post-SUV) and the SUVmax reduction rate (ΔSUV%) were used to evaluate the response to preoperative CRT. Correlations among SUVmax, histopathological response, and expression of cancer antigen Ki-67 and hypoxia-inducible factor-1α (HIF-1α) were analyzed. Results: Preoperative CRT significantly reduced intratumoral FDG uptake (P<0.001). The pre-SUV and post-SUV were significantly lower in patients with a pathological complete response (pCR) than in those with a non-pCR (pre-SUV P=0.037; post-SUV P=0.001). ΔSUV% was higher in patients with pCR than in those with non-pCR (P=0.029). The pre-SUV was significantly correlated with Ki-67 and HIF-1α expression in pretreatment biopsy specimens (Ki-67 P=0.046, R=0.292; HIF-1α P=0.007, R=0.385). The expression of both Ki-67 and HIF-1α was significantly lower in patients with pCR than in those with non-pCR (Ki-67 P<0.001; HIF-1α P<0.001). Conclusions: Low pre-SUV and post-SUV and high ΔSUV% may predict a good histopathological response to preoperative CRT. Ki-67 and HIF-1α expression in pretreatment biopsy specimens were predictors of histopathological response to preoperative CRT. | |
| 540 | |a Japan Society of Clinical Oncology, 2014 | ||
| 690 | 7 | |a Oral squamous cell carcinoma |2 nationallicence | |
| 690 | 7 | |a FDG-PET |2 nationallicence | |
| 690 | 7 | |a Standardized uptake value |2 nationallicence | |
| 690 | 7 | |a Ki-67 |2 nationallicence | |
| 690 | 7 | |a HIF-1α |2 nationallicence | |
| 690 | 7 | |a Chemoradiotherapy |2 nationallicence | |
| 700 | 1 | |a Shimomura |D Hiroyuki |u Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan |4 aut | |
| 700 | 1 | |a Sasahira |D Tomonori |u Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan |4 aut | |
| 700 | 1 | |a Yamanaka |D Yasutsugu |u Department of Dentistry and Oral Surgery, Takai Hospital, 461-2 Kuranosho-cho, 632-0006, Tenri, Nara, Japan |4 aut | |
| 700 | 1 | |a Kurihara |D Miyako |u Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan |4 aut | |
| 700 | 1 | |a Imai |D Yuichiro |u Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan |4 aut | |
| 700 | 1 | |a Tamaki |D Shigehiro |u Department of Dentistry and Oral Surgery, Takai Hospital, 461-2 Kuranosho-cho, 632-0006, Tenri, Nara, Japan |4 aut | |
| 700 | 1 | |a Yamakawa |D Nobuhiro |u Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan |4 aut | |
| 700 | 1 | |a Shirone |D Norihisa |u Department of Radiology, Takai Hospital, Tenri, Nara, Japan |4 aut | |
| 700 | 1 | |a Hasegawa |D Masatoshi |u Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan |4 aut | |
| 700 | 1 | |a Kuniyasu |D Hiroki |u Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan |4 aut | |
| 700 | 1 | |a Kirita |D Tadaaki |u Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/2(2015-04-01), 308-316 |x 1341-9625 |q 20:2<308 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-014-0711-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-014-0711-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shimomura |D Hiroyuki |u Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sasahira |D Tomonori |u Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yamanaka |D Yasutsugu |u Department of Dentistry and Oral Surgery, Takai Hospital, 461-2 Kuranosho-cho, 632-0006, Tenri, Nara, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kurihara |D Miyako |u Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Imai |D Yuichiro |u Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tamaki |D Shigehiro |u Department of Dentistry and Oral Surgery, Takai Hospital, 461-2 Kuranosho-cho, 632-0006, Tenri, Nara, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yamakawa |D Nobuhiro |u Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shirone |D Norihisa |u Department of Radiology, Takai Hospital, Tenri, Nara, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hasegawa |D Masatoshi |u Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kuniyasu |D Hiroki |u Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kirita |D Tadaaki |u Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/2(2015-04-01), 308-316 |x 1341-9625 |q 20:2<308 |1 2015 |2 20 |o 10147 | ||