caa a22 4500 605491844 CHVBK 20210128100512.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10147-014-0711-5 doi (NATIONALLICENCE)springer-10.1007/s10147-014-0711-5 [18F]fluoro-2-deoxyglucose-positron emission tomography for the assessment of histopathological response after preoperative chemoradiotherapy in advanced oral squamous cell carcinoma [Elektronische Daten] [Hiroyuki Shimomura, Tomonori Sasahira, Yasutsugu Yamanaka, Miyako Kurihara, Yuichiro Imai, Shigehiro Tamaki, Nobuhiro Yamakawa, Norihisa Shirone, Masatoshi Hasegawa, Hiroki Kuniyasu, Tadaaki Kirita] Background: [18F]fluoro-2-deoxyglucose-positron emission tomography (FDG-PET) is widely used to evaluate tumor metabolic activity. The aim of this study was to evaluate the usefulness of FDG-PET in assessing the histopathological response to preoperative concurrent chemoradiotherapy (CRT) in patients with oral squamous cell carcinoma (OSCC). Methods: Forty-five patients with resectable advanced OSCC who had received preoperative CRT followed by tumor ablative surgery between January 2004 and December 2011 were included in the study. All patients underwent FDG-PET before and after preoperative CRT. The maximum standardized uptake value (SUVmax) before (pre-SUV) and after preoperative CRT (post-SUV) and the SUVmax reduction rate (ΔSUV%) were used to evaluate the response to preoperative CRT. Correlations among SUVmax, histopathological response, and expression of cancer antigen Ki-67 and hypoxia-inducible factor-1α (HIF-1α) were analyzed. Results: Preoperative CRT significantly reduced intratumoral FDG uptake (P<0.001). The pre-SUV and post-SUV were significantly lower in patients with a pathological complete response (pCR) than in those with a non-pCR (pre-SUV P=0.037; post-SUV P=0.001). ΔSUV% was higher in patients with pCR than in those with non-pCR (P=0.029). The pre-SUV was significantly correlated with Ki-67 and HIF-1α expression in pretreatment biopsy specimens (Ki-67 P=0.046, R=0.292; HIF-1α P=0.007, R=0.385). The expression of both Ki-67 and HIF-1α was significantly lower in patients with pCR than in those with non-pCR (Ki-67 P<0.001; HIF-1α P<0.001). Conclusions: Low pre-SUV and post-SUV and high ΔSUV% may predict a good histopathological response to preoperative CRT. Ki-67 and HIF-1α expression in pretreatment biopsy specimens were predictors of histopathological response to preoperative CRT. Japan Society of Clinical Oncology, 2014 Oral squamous cell carcinoma nationallicence FDG-PET nationallicence Standardized uptake value nationallicence Ki-67 nationallicence HIF-1α nationallicence Chemoradiotherapy nationallicence Shimomura Hiroyuki Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Sasahira Tomonori Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan aut Yamanaka Yasutsugu Department of Dentistry and Oral Surgery, Takai Hospital, 461-2 Kuranosho-cho, 632-0006, Tenri, Nara, Japan aut Kurihara Miyako Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan aut Imai Yuichiro Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Tamaki Shigehiro Department of Dentistry and Oral Surgery, Takai Hospital, 461-2 Kuranosho-cho, 632-0006, Tenri, Nara, Japan aut Yamakawa Nobuhiro Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Shirone Norihisa Department of Radiology, Takai Hospital, Tenri, Nara, Japan aut Hasegawa Masatoshi Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan aut Kuniyasu Hiroki Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan aut Kirita Tadaaki Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 308-316 1341-9625 20:2<308 2015 20 10147 https://doi.org/10.1007/s10147-014-0711-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0711-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shimomura Hiroyuki Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Sasahira Tomonori Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Yamanaka Yasutsugu Department of Dentistry and Oral Surgery, Takai Hospital, 461-2 Kuranosho-cho, 632-0006, Tenri, Nara, Japan aut NATIONALLICENCE 700 1- Kurihara Miyako Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Imai Yuichiro Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Tamaki Shigehiro Department of Dentistry and Oral Surgery, Takai Hospital, 461-2 Kuranosho-cho, 632-0006, Tenri, Nara, Japan aut NATIONALLICENCE 700 1- Yamakawa Nobuhiro Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Shirone Norihisa Department of Radiology, Takai Hospital, Tenri, Nara, Japan aut NATIONALLICENCE 700 1- Hasegawa Masatoshi Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Kuniyasu Hiroki Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Kirita Tadaaki Department of Oral and Maxillofacial Surgery, Nara Medical University, 804 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 308-316 1341-9625 20:2<308 2015 20 10147