Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significance
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| 024 | 7 | 0 | |a 10.1007/s10147-014-0701-7 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10147-014-0701-7 | ||
| 245 | 0 | 0 | |a Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significance |h [Elektronische Daten] |c [Yiting Geng, Hui Wang, Changqing Lu, Qing Li, Bin Xu, Jingting Jiang, Changping Wu] |
| 520 | 3 | |a Objective: Immune escape plays an important role in tumor progression. In the present study, the expression of B7-H1, B7-H4 and Foxp3 involved in immune escape in gastric carcinoma was investigated and the corresponding clinical significance was evaluated. Methods: Immunohistochemistry was used to detect the expression of B7-H1, B7-H4 and Foxp3 in 100 gastric cancer specimens, and 30 paracarcinoma tissues were used as the control. Results: Both B7-H1 and B7-H4 showed high expression levels in gastric cancer tissues (65.0 and 71.0%, respectively), and the expressions of B7-H1 and B7-H4 were positively correlated with the depth of tumor invasion, lymph node metastasis and American Joint Committee on Cancer (AJCC) stage (P<0.05). The number of Foxp3+ Tregs was much higher in gastric cancer tissues than control tissues, which was positively correlated with lymph node metastasis (P<0.05). Similarly, a positive correlation between B7-H1 or B7-H4 expression and the number of Foxp3+ Tregs was observed. The median overall survival rate of patients with high expression of B7-H1, B7-H4 and Foxp3 was significantly poorer than that of patients with low expression of these proteins (P<0.05). Cox regression multivariate analysis confirmed that lymph node metastasis, AJCC stage, and B7-H1 and Foxp3 overexpression were independent prognostic factors. Conclusion: B7-H1, B7-H4 and Foxp3 were overexpressed in gastric cancer tissues. B7-H1 and Foxp3 are negative prognostic factors for patients with gastric cancer. | |
| 540 | |a Japan Society of Clinical Oncology, 2014 | ||
| 690 | 7 | |a Gastric cancer |2 nationallicence | |
| 690 | 7 | |a B7-H1 |2 nationallicence | |
| 690 | 7 | |a B7-H4 |2 nationallicence | |
| 690 | 7 | |a Foxp3 |2 nationallicence | |
| 690 | 7 | |a Tregs |2 nationallicence | |
| 690 | 7 | |a Costimulatory molecule |2 nationallicence | |
| 700 | 1 | |a Geng |D Yiting |u Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China |4 aut | |
| 700 | 1 | |a Wang |D Hui |u Department of Pathology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, People's Republic of China |4 aut | |
| 700 | 1 | |a Lu |D Changqing |u Department of Pathology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, People's Republic of China |4 aut | |
| 700 | 1 | |a Li |D Qing |u Department of Pathology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, People's Republic of China |4 aut | |
| 700 | 1 | |a Xu |D Bin |u Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China |4 aut | |
| 700 | 1 | |a Jiang |D Jingting |u Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China |4 aut | |
| 700 | 1 | |a Wu |D Changping |u Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/2(2015-04-01), 273-281 |x 1341-9625 |q 20:2<273 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-014-0701-7 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-014-0701-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Geng |D Yiting |u Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wang |D Hui |u Department of Pathology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lu |D Changqing |u Department of Pathology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Li |D Qing |u Department of Pathology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Xu |D Bin |u Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jiang |D Jingting |u Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wu |D Changping |u Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/2(2015-04-01), 273-281 |x 1341-9625 |q 20:2<273 |1 2015 |2 20 |o 10147 | ||