caa a22 4500 605491879 CHVBK 20210128100512.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10147-014-0701-7 doi (NATIONALLICENCE)springer-10.1007/s10147-014-0701-7 Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significance [Elektronische Daten] [Yiting Geng, Hui Wang, Changqing Lu, Qing Li, Bin Xu, Jingting Jiang, Changping Wu] Objective: Immune escape plays an important role in tumor progression. In the present study, the expression of B7-H1, B7-H4 and Foxp3 involved in immune escape in gastric carcinoma was investigated and the corresponding clinical significance was evaluated. Methods: Immunohistochemistry was used to detect the expression of B7-H1, B7-H4 and Foxp3 in 100 gastric cancer specimens, and 30 paracarcinoma tissues were used as the control. Results: Both B7-H1 and B7-H4 showed high expression levels in gastric cancer tissues (65.0 and 71.0%, respectively), and the expressions of B7-H1 and B7-H4 were positively correlated with the depth of tumor invasion, lymph node metastasis and American Joint Committee on Cancer (AJCC) stage (P<0.05). The number of Foxp3+ Tregs was much higher in gastric cancer tissues than control tissues, which was positively correlated with lymph node metastasis (P<0.05). Similarly, a positive correlation between B7-H1 or B7-H4 expression and the number of Foxp3+ Tregs was observed. The median overall survival rate of patients with high expression of B7-H1, B7-H4 and Foxp3 was significantly poorer than that of patients with low expression of these proteins (P<0.05). Cox regression multivariate analysis confirmed that lymph node metastasis, AJCC stage, and B7-H1 and Foxp3 overexpression were independent prognostic factors. Conclusion: B7-H1, B7-H4 and Foxp3 were overexpressed in gastric cancer tissues. B7-H1 and Foxp3 are negative prognostic factors for patients with gastric cancer. Japan Society of Clinical Oncology, 2014 Gastric cancer nationallicence B7-H1 nationallicence B7-H4 nationallicence Foxp3 nationallicence Tregs nationallicence Costimulatory molecule nationallicence Geng Yiting Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China aut Wang Hui Department of Pathology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, People's Republic of China aut Lu Changqing Department of Pathology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, People's Republic of China aut Li Qing Department of Pathology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, People's Republic of China aut Xu Bin Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China aut Jiang Jingting Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China aut Wu Changping Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China aut International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 273-281 1341-9625 20:2<273 2015 20 10147 https://doi.org/10.1007/s10147-014-0701-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0701-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Geng Yiting Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China aut NATIONALLICENCE 700 1- Wang Hui Department of Pathology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, People's Republic of China aut NATIONALLICENCE 700 1- Lu Changqing Department of Pathology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, People's Republic of China aut NATIONALLICENCE 700 1- Li Qing Department of Pathology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, People's Republic of China aut NATIONALLICENCE 700 1- Xu Bin Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China aut NATIONALLICENCE 700 1- Jiang Jingting Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China aut NATIONALLICENCE 700 1- Wu Changping Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213003, Changzhou, Jiangsu, People's Republic of China aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 273-281 1341-9625 20:2<273 2015 20 10147