caa a22 4500 605491887 CHVBK 20210128100512.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10147-014-0708-0 doi (NATIONALLICENCE)springer-10.1007/s10147-014-0708-0 Opioid needs of terminally ill patients with gynecologic malignancies [Elektronische Daten] [Fumi Utsumi, Hiroaki Kajiyama, Jun Sakata, Makiko Higashi, Kaoru Niimi, Ryuichiro Sekiya, Hiroko Mitsui, Shiro Suzuki, Tomokazu Umezu, Mika Mizuno, Eiko Yamamoto, Kiyosumi Shibata, Fumitaka Kikkawa] Background: Little is known about patterns and predictive factors regarding opioid use for terminally ill patients with gynecologic malignancies. The aim of this study was to elucidate predictors affecting opioid requirements of end-of-life patients with gynecologic malignancies. Methods: A retrospective study was carried out on patients with gynecological malignancies admitted to our institute and died during the years 2002 to 2012. The association between maximum opioid dose and factors affecting opioid requirements were examined. Data extracted from medical records included age, site of primary cancer, maximum total dose of opioids prescribed over 24h, the site of recurrence and metastasis, procedures performed during the hospital stay, total number of chemotherapy courses and overall survival. Results: The study identified 189 patients. Most patients had ovarian cancer (42.3%) followed by cervical cancer (28.0%) and then corpus malignancy (27.0%). Opioid requirements decreased with increasing age, especially from the 50s onward. This was particularly marked in cervical cancer patients. In addition, pelvic metastasis was associated with the maximum dose of opioids and the average opioid use was highest in patients with cervical cancer. Conclusion: Young age and pelvic invasion were significant predictive factors regarding opioid requirements. Additionally, cervical cancer patients may require more opioids among those with gynecologic malignancies. Japan Society of Clinical Oncology, 2014 Cancer-related pain nationallicence Gynecologic malignancy nationallicence Opioid intake nationallicence Age nationallicence Pelvic invasion nationallicence Utsumi Fumi Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut Kajiyama Hiroaki Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut Sakata Jun Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut Higashi Makiko Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut Niimi Kaoru Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut Sekiya Ryuichiro Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut Mitsui Hiroko Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut Suzuki Shiro Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut Umezu Tomokazu Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut Mizuno Mika Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut Yamamoto Eiko Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut Shibata Kiyosumi Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut Kikkawa Fumitaka Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 405-410 1341-9625 20:2<405 2015 20 10147 https://doi.org/10.1007/s10147-014-0708-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0708-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Utsumi Fumi Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Kajiyama Hiroaki Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Sakata Jun Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Higashi Makiko Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Niimi Kaoru Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Sekiya Ryuichiro Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Mitsui Hiroko Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Suzuki Shiro Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Umezu Tomokazu Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Mizuno Mika Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Yamamoto Eiko Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Shibata Kiyosumi Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Kikkawa Fumitaka Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 405-410 1341-9625 20:2<405 2015 20 10147