Disease control and clinicopathological prognostic factors of total pharyngolaryngectomy for hypopharyngeal cancer: a single-center study
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| 024 | 7 | 0 | |a 10.1007/s10147-014-0709-z |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10147-014-0709-z | ||
| 245 | 0 | 0 | |a Disease control and clinicopathological prognostic factors of total pharyngolaryngectomy for hypopharyngeal cancer: a single-center study |h [Elektronische Daten] |c [Go Omura, Mizuo Ando, Yuki Saito, Kenya Kobayashi, Tatsuya Yamasoba, Takahiro Asakage] |
| 520 | 3 | |a Background: Total pharyngolaryngectomy (TPL) is a conventional and standard surgical method for locoregional control of advanced hypopharyngeal cancer (HPC). This study aimed to define the clinicopathological prognostic factors of TPL by evaluating our surgical experience of TPL in the treatment of HPCs. Methods: We retrospectively reviewed the clinical charts of patients with HPC who were treated between 1995 and 2011 at the University of Tokyo Hospital and enrolled 119 patients who underwent TPL as an initial curative treatment. Results: The mean follow-up period was 46months (range, 2-164months). The 5-year overall survival (OS), disease-specific survival (DSS), locoregional control rates, and relapse-free survival for all patients were 44, 53, 76, and 50%, respectively. In multivariate analysis, the number of ≥4 metastatic lymph nodes (LNs) was a significant poor prognostic factor for both OS and DSS (p=0.03 and p=0.01). Patients with moderate to severe comorbidities had poor prognoses for OS (p=0.002). In addition, patients with the number of ≥4 metastatic LNs had a higher incidence of distant metastases (p<0.0001). Conclusions: The locoregional control rate following TPL was acceptable and the number of metastatic LNs was associated with the incidence of distant metastases. | |
| 540 | |a Japan Society of Clinical Oncology, 2014 | ||
| 690 | 7 | |a Hypopharyngeal cancer |2 nationallicence | |
| 690 | 7 | |a Total pharyngolaryngectomy |2 nationallicence | |
| 690 | 7 | |a ≥4 metastatic lymph nodes |2 nationallicence | |
| 690 | 7 | |a Distant metastases |2 nationallicence | |
| 690 | 7 | |a Comorbidity |2 nationallicence | |
| 700 | 1 | |a Omura |D Go |u Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Ando |D Mizuo |u Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Saito |D Yuki |u Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Kobayashi |D Kenya |u Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Yamasoba |D Tatsuya |u Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Asakage |D Takahiro |u Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/2(2015-04-01), 290-297 |x 1341-9625 |q 20:2<290 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-014-0709-z |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-014-0709-z |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Omura |D Go |u Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ando |D Mizuo |u Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Saito |D Yuki |u Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kobayashi |D Kenya |u Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yamasoba |D Tatsuya |u Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Asakage |D Takahiro |u Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/2(2015-04-01), 290-297 |x 1341-9625 |q 20:2<290 |1 2015 |2 20 |o 10147 | ||