caa a22 4500 605491909 CHVBK 20210128100512.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10147-014-0709-z doi (NATIONALLICENCE)springer-10.1007/s10147-014-0709-z Disease control and clinicopathological prognostic factors of total pharyngolaryngectomy for hypopharyngeal cancer: a single-center study [Elektronische Daten] [Go Omura, Mizuo Ando, Yuki Saito, Kenya Kobayashi, Tatsuya Yamasoba, Takahiro Asakage] Background: Total pharyngolaryngectomy (TPL) is a conventional and standard surgical method for locoregional control of advanced hypopharyngeal cancer (HPC). This study aimed to define the clinicopathological prognostic factors of TPL by evaluating our surgical experience of TPL in the treatment of HPCs. Methods: We retrospectively reviewed the clinical charts of patients with HPC who were treated between 1995 and 2011 at the University of Tokyo Hospital and enrolled 119 patients who underwent TPL as an initial curative treatment. Results: The mean follow-up period was 46months (range, 2-164months). The 5-year overall survival (OS), disease-specific survival (DSS), locoregional control rates, and relapse-free survival for all patients were 44, 53, 76, and 50%, respectively. In multivariate analysis, the number of ≥4 metastatic lymph nodes (LNs) was a significant poor prognostic factor for both OS and DSS (p=0.03 and p=0.01). Patients with moderate to severe comorbidities had poor prognoses for OS (p=0.002). In addition, patients with the number of ≥4 metastatic LNs had a higher incidence of distant metastases (p<0.0001). Conclusions: The locoregional control rate following TPL was acceptable and the number of metastatic LNs was associated with the incidence of distant metastases. Japan Society of Clinical Oncology, 2014 Hypopharyngeal cancer nationallicence Total pharyngolaryngectomy nationallicence ≥4 metastatic lymph nodes nationallicence Distant metastases nationallicence Comorbidity nationallicence Omura Go Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut Ando Mizuo Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut Saito Yuki Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut Kobayashi Kenya Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut Yamasoba Tatsuya Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut Asakage Takahiro Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 290-297 1341-9625 20:2<290 2015 20 10147 https://doi.org/10.1007/s10147-014-0709-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0709-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Omura Go Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Ando Mizuo Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Saito Yuki Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Kobayashi Kenya Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamasoba Tatsuya Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Asakage Takahiro Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/2(2015-04-01), 290-297 1341-9625 20:2<290 2015 20 10147