caa a22 4500 605491933 CHVBK 20210128100512.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00261-014-0200-3 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0200-3 Value of gadoxetate biliary transit time in determining hepatocyte function [Elektronische Daten] [Jianwei Wu, Hui Li, Yuning Lin, Ziqian Chen, Qun Zhong, Hong Gao, Liyuan Fu, Kumar Sandrasegaran] Objective: To determine if transit time for excretion of gadoxetate into major bile ducts and duodenum correlates with clinical models of hepatocellular function. Methods: This retrospective research was approved by the Institutional Review Board with waiver of informed consent. Search of the radiology database from January 1, 2013 to March 4, 2014 revealed 84 patients with chronic liver disease (65 males, mean age 47years). Eighteen control subjects with no known liver disease or risk factors were also enrolled for analysis (9 males, mean age 43years). MRI was performed with hepatobiliary phases at 10, 15, 20, and 25min after injection of 0.025 mmol/kg of gadoxetate (Primovist, Bayer HealthCare, Shanghai, China). The time of excreted contrast appearing in the biliary tree and in the duodenum was recorded. Linear trend analysis was performed to determine the relationship between excretion time and hepatic function. Results: The patient cohort was stratified by Child-Pugh classification (A, B, and C with n=53, 27, and 4, respectively). Arrival of gadoxetate in the gall bladder at 10-min hepatobiliary phase was seen in 87% of control group and 45% of Child-Pugh A group (p=0.02). There was no difference between these groups for later hepatobiliary phases. The arrival of biliary contrast in the right hepatic duct, common bile duct, and gall bladder were significantly earlier in the Child-Pugh A group compared to the Child-Pugh B/C group at all hepatobiliary phases after 10min (p<0.05). Linear trend analysis showed that biliary transit times were significantly delayed with worsening liver function (p=0.01). There was no difference in entry time of gadoxetate into the duodenum between the normal, Child-Pugh A, and Child-Pugh B/C groups. Conclusions: The transit time for gadoxetate to appear in extrahepatic duct is a reasonable indicator of liver function, and may be included in radiology reports. The appearance in the duodenum, however, may depend on factors other than liver function, such as the physiology of the gallbladder and sphincter of Oddi. Springer Science+Business Media New York, 2014 Magnetic resonance imaging nationallicence Cirrhosis nationallicence Gadoxetate nationallicence Hepatobiliary phase nationallicence Wu Jianwei Department of Radiology, Nanjing Jingdu Hospital, Nanjing, Jiangsu, China aut Li Hui Department of Radiology, Fuzhou General Hospital of Nanjing Command, PLA, 156 West Second Ring Road, Fuzhou, Fujian, China aut Lin Yuning Department of Radiology, Fuzhou General Hospital of Nanjing Command, PLA, 156 West Second Ring Road, Fuzhou, Fujian, China aut Chen Ziqian Department of Radiology, Fuzhou General Hospital of Nanjing Command, PLA, 156 West Second Ring Road, Fuzhou, Fujian, China aut Zhong Qun Department of Radiology, Fuzhou General Hospital of Nanjing Command, PLA, 156 West Second Ring Road, Fuzhou, Fujian, China aut Gao Hong Department of Radiology, Nanjing Jingdu Hospital, Nanjing, Jiangsu, China aut Fu Liyuan Department of Radiology, Fuzhou General Hospital of Nanjing Command, PLA, 156 West Second Ring Road, Fuzhou, Fujian, China aut Sandrasegaran Kumar Department of Radiology, Indiana University School of Medicine, Indianapolis, IN, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 95-101 0942-8925 40:1<95 2015 40 261 https://doi.org/10.1007/s00261-014-0200-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0200-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wu Jianwei Department of Radiology, Nanjing Jingdu Hospital, Nanjing, Jiangsu, China aut NATIONALLICENCE 700 1- Li Hui Department of Radiology, Fuzhou General Hospital of Nanjing Command, PLA, 156 West Second Ring Road, Fuzhou, Fujian, China aut NATIONALLICENCE 700 1- Lin Yuning Department of Radiology, Fuzhou General Hospital of Nanjing Command, PLA, 156 West Second Ring Road, Fuzhou, Fujian, China aut NATIONALLICENCE 700 1- Chen Ziqian Department of Radiology, Fuzhou General Hospital of Nanjing Command, PLA, 156 West Second Ring Road, Fuzhou, Fujian, China aut NATIONALLICENCE 700 1- Zhong Qun Department of Radiology, Fuzhou General Hospital of Nanjing Command, PLA, 156 West Second Ring Road, Fuzhou, Fujian, China aut NATIONALLICENCE 700 1- Gao Hong Department of Radiology, Nanjing Jingdu Hospital, Nanjing, Jiangsu, China aut NATIONALLICENCE 700 1- Fu Liyuan Department of Radiology, Fuzhou General Hospital of Nanjing Command, PLA, 156 West Second Ring Road, Fuzhou, Fujian, China aut NATIONALLICENCE 700 1- Sandrasegaran Kumar Department of Radiology, Indiana University School of Medicine, Indianapolis, IN, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 95-101 0942-8925 40:1<95 2015 40 261