Cross-sectional and longitudinal evaluation of liver volume and total liver fat burden in adults with nonalcoholic steatohepatitis
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| 008 | 210128e20150101xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00261-014-0175-0 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-014-0175-0 | ||
| 245 | 0 | 0 | |a Cross-sectional and longitudinal evaluation of liver volume and total liver fat burden in adults with nonalcoholic steatohepatitis |h [Elektronische Daten] |c [An Tang, Joshua Chen, Thuy-Anh Le, Christopher Changchien, Gavin Hamilton, Michael Middleton, Rohit Loomba, Claude Sirlin] |
| 520 | 3 | |a Purpose: To explore the cross-sectional and longitudinal relationships between fractional liver fat content, liver volume, and total liver fat burden. Methods: In 43 adults with non-alcoholic steatohepatitis participating in a clinical trial, liver volume was estimated by segmentation of magnitude-based low-flip-angle multiecho GRE images. The liver mean proton density fat fraction (PDFF) was calculated. The total liver fat index (TLFI) was estimated as the product of liver mean PDFF and liver volume. Linear regression analyses were performed. Results: Cross-sectional analyses revealed statistically significant relationships between TLFI and liver mean PDFF (R 2=0.740 baseline/0.791 follow-up, P<0.001 baseline/P<0.001 follow-up), and between TLFI and liver volume (R 2=0.352/0.452, P<0.001/<0.001). Longitudinal analyses revealed statistically significant relationships between liver volume change and liver mean PDFF change (R 2=0.556, P<0.001), between TLFI change and liver mean PDFF change (R 2=0.920, P<0.001), and between TLFI change and liver volume change (R 2=0.735, P<0.001). Conclusion: Liver segmentation in combination with MRI-based PDFF estimation may be used to monitor liver volume, liver mean PDFF, and TLFI in a clinical trial. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Liver |2 nationallicence | |
| 690 | 7 | |a Fatty liver |2 nationallicence | |
| 690 | 7 | |a Magnetic resonance imaging |2 nationallicence | |
| 690 | 7 | |a Organ size |2 nationallicence | |
| 690 | 7 | |a Biological markers |2 nationallicence | |
| 690 | 7 | |a MRI : Magnetic resonance imaging |2 nationallicence | |
| 690 | 7 | |a MRS : Magnetic resonance spectroscopy |2 nationallicence | |
| 690 | 7 | |a NAFLD : Nonalcoholic fatty liver disease |2 nationallicence | |
| 690 | 7 | |a NASH : Nonalcoholic steatohepatitis |2 nationallicence | |
| 690 | 7 | |a PDFF : Proton density fat fraction |2 nationallicence | |
| 690 | 7 | |a ROI : Region of interest |2 nationallicence | |
| 690 | 7 | |a TLFI : Total liver fat index |2 nationallicence | |
| 700 | 1 | |a Tang |D An |u Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA |4 aut | |
| 700 | 1 | |a Chen |D Joshua |u Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA |4 aut | |
| 700 | 1 | |a Le |D Thuy-Anh |u Division of Gastroenterology, Department of Medicine, and Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA |4 aut | |
| 700 | 1 | |a Changchien |D Christopher |u Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA |4 aut | |
| 700 | 1 | |a Hamilton |D Gavin |u Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA |4 aut | |
| 700 | 1 | |a Middleton |D Michael |u Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA |4 aut | |
| 700 | 1 | |a Loomba |D Rohit |u Division of Gastroenterology, Department of Medicine, and Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA |4 aut | |
| 700 | 1 | |a Sirlin |D Claude |u Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/1(2015-01-01), 26-37 |x 0942-8925 |q 40:1<26 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-014-0175-0 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-014-0175-0 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tang |D An |u Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chen |D Joshua |u Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Le |D Thuy-Anh |u Division of Gastroenterology, Department of Medicine, and Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Changchien |D Christopher |u Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hamilton |D Gavin |u Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Middleton |D Michael |u Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Loomba |D Rohit |u Division of Gastroenterology, Department of Medicine, and Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sirlin |D Claude |u Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/1(2015-01-01), 26-37 |x 0942-8925 |q 40:1<26 |1 2015 |2 40 |o 261 | ||