caa a22 4500 605491976 CHVBK 20210128100512.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00261-014-0175-0 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0175-0 Cross-sectional and longitudinal evaluation of liver volume and total liver fat burden in adults with nonalcoholic steatohepatitis [Elektronische Daten] [An Tang, Joshua Chen, Thuy-Anh Le, Christopher Changchien, Gavin Hamilton, Michael Middleton, Rohit Loomba, Claude Sirlin] Purpose: To explore the cross-sectional and longitudinal relationships between fractional liver fat content, liver volume, and total liver fat burden. Methods: In 43 adults with non-alcoholic steatohepatitis participating in a clinical trial, liver volume was estimated by segmentation of magnitude-based low-flip-angle multiecho GRE images. The liver mean proton density fat fraction (PDFF) was calculated. The total liver fat index (TLFI) was estimated as the product of liver mean PDFF and liver volume. Linear regression analyses were performed. Results: Cross-sectional analyses revealed statistically significant relationships between TLFI and liver mean PDFF (R 2=0.740 baseline/0.791 follow-up, P<0.001 baseline/P<0.001 follow-up), and between TLFI and liver volume (R 2=0.352/0.452, P<0.001/<0.001). Longitudinal analyses revealed statistically significant relationships between liver volume change and liver mean PDFF change (R 2=0.556, P<0.001), between TLFI change and liver mean PDFF change (R 2=0.920, P<0.001), and between TLFI change and liver volume change (R 2=0.735, P<0.001). Conclusion: Liver segmentation in combination with MRI-based PDFF estimation may be used to monitor liver volume, liver mean PDFF, and TLFI in a clinical trial. Springer Science+Business Media New York, 2014 Liver nationallicence Fatty liver nationallicence Magnetic resonance imaging nationallicence Organ size nationallicence Biological markers nationallicence MRI : Magnetic resonance imaging nationallicence MRS : Magnetic resonance spectroscopy nationallicence NAFLD : Nonalcoholic fatty liver disease nationallicence NASH : Nonalcoholic steatohepatitis nationallicence PDFF : Proton density fat fraction nationallicence ROI : Region of interest nationallicence TLFI : Total liver fat index nationallicence Tang An Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA aut Chen Joshua Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA aut Le Thuy-Anh Division of Gastroenterology, Department of Medicine, and Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA aut Changchien Christopher Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA aut Hamilton Gavin Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA aut Middleton Michael Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA aut Loomba Rohit Division of Gastroenterology, Department of Medicine, and Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA aut Sirlin Claude Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 26-37 0942-8925 40:1<26 2015 40 261 https://doi.org/10.1007/s00261-014-0175-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0175-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tang An Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA aut NATIONALLICENCE 700 1- Chen Joshua Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA aut NATIONALLICENCE 700 1- Le Thuy-Anh Division of Gastroenterology, Department of Medicine, and Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Changchien Christopher Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA aut NATIONALLICENCE 700 1- Hamilton Gavin Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA aut NATIONALLICENCE 700 1- Middleton Michael Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA aut NATIONALLICENCE 700 1- Loomba Rohit Division of Gastroenterology, Department of Medicine, and Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Sirlin Claude Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, 92103-8226, San Diego, CA, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 26-37 0942-8925 40:1<26 2015 40 261