caa a22 4500 605491992 CHVBK 20210128100512.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00261-014-0199-5 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0199-5 Multi-parametric MRI findings of transitional zone prostate cancers: correlation with 3-dimensional transperineal mapping biopsy [Elektronische Daten] [Sajal Pokharel, Nayana Patel, Kavita Garg, Francisco La Rosa, Paul Arangua, Clifford Jones, E. Crawford] Purpose A preliminary project to correlate MR findings with mapping prostate biopsy to help differentiate malignant transitional zone lesions form benign prostatic hyperplasia (BPH) nodules. Materials and Methods Institutional IRB approved retrospective study with 14 patients suspected of having prostate cancer who underwent both prostate 3T MRI using endorectal coil and 3D transperineal mapping prostate biopsy. MR exams were independently reviewed by two abdominal radiologists blinded to pathology with disagreement resolved by consensus. An MRI lesion was defined as having hypointense T2 signal subjectively without corresponding T1 high signal intensity and low signal on ADC maps in the central gland. Mapping biopsy consisted of systematic transperineal US guided biopsy with 55-108 cores per patient. Results Twenty-nine lesions were detected on MRI. Of these, 13 correlated with Gleason 6 or higher biopsy samples. 16 were biopsy negative. Among the various MRI characteristics assessed, lack of T2 hypointense rim demonstrated the highest specificity (93%) and positive predictive value (89%). Highest sensitivity (85%) and negative predictive value (78%) were seen with ill-defined nodules. When suspicious MR characteristics were combined, the specificity and PPV rose to 100% while sensitivity decreased to 45% and NPV decreased to 73%. Conclusions Preliminary study indicates MR findings which can help differentiate a BPH nodule from transitional zone prostate cancers which could help direct biopsy in the large and growing number of people suspected of having prostate cancer. Further work will be needed for validation. Springer Science+Business Media New York, 2014 Prostate nationallicence MRI nationallicence Transitional zone nationallicence Mapping biopsy nationallicence Pokharel Sajal University of Colorado School of Medicine, 12401 E 19th Ave, Mailstop L954, 80045, Aurora, CO, USA aut Patel Nayana University of Colorado School of Medicine, 12401 E 19th Ave, Mailstop L954, 80045, Aurora, CO, USA aut Garg Kavita University of Colorado School of Medicine, 12401 E 19th Ave, Mailstop L954, 80045, Aurora, CO, USA aut La Rosa Francisco University of Colorado School of Medicine, 12401 E 19th Ave, Mailstop L954, 80045, Aurora, CO, USA aut Arangua Paul University of Colorado School of Medicine, 12401 E 19th Ave, Mailstop L954, 80045, Aurora, CO, USA aut Jones Clifford University of Colorado School of Medicine, 12401 E 19th Ave, Mailstop L954, 80045, Aurora, CO, USA aut Crawford E. University of Colorado School of Medicine, 12401 E 19th Ave, Mailstop L954, 80045, Aurora, CO, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 143-150 0942-8925 40:1<143 2015 40 261 https://doi.org/10.1007/s00261-014-0199-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0199-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pokharel Sajal University of Colorado School of Medicine, 12401 E 19th Ave, Mailstop L954, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- Patel Nayana University of Colorado School of Medicine, 12401 E 19th Ave, Mailstop L954, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- Garg Kavita University of Colorado School of Medicine, 12401 E 19th Ave, Mailstop L954, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- La Rosa Francisco University of Colorado School of Medicine, 12401 E 19th Ave, Mailstop L954, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- Arangua Paul University of Colorado School of Medicine, 12401 E 19th Ave, Mailstop L954, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- Jones Clifford University of Colorado School of Medicine, 12401 E 19th Ave, Mailstop L954, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- Crawford E. University of Colorado School of Medicine, 12401 E 19th Ave, Mailstop L954, 80045, Aurora, CO, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 143-150 0942-8925 40:1<143 2015 40 261