18F-FDG-PET/CT is of limited value in primary staging of early stage cervical cancer
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 60549200X | ||
| 003 | CHVBK | ||
| 005 | 20210128100512.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150101xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00261-014-0194-x |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-014-0194-x | ||
| 245 | 0 | 0 | |a 18F-FDG-PET/CT is of limited value in primary staging of early stage cervical cancer |h [Elektronische Daten] |c [Dearbhail Driscoll, Darragh Halpenny, Ciaran Johnston, Niall Sheehy, Mary Keogan] |
| 520 | 3 | |a Purpose: To assess the clinical benefit of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG-PET/CT) in evaluating pelvic lymph nodes in patients with early stage cervical cancer (FIGO stage 1a-1b1), who have magnetic resonance imaging (MRI)-defined lymph node negative disease, with histopathologic results as the reference standard. Materials and Methods: We assessed one hundred and seventy nine sequential 18F-FDG-PET/CT scans in women with newly diagnosed cervical carcinoma between January 2009 and September 2011. 47 of these patients had early stage disease (FIGO stage 1a-1b1) with no suspicious lymph nodes on MRI. 18F-FDG-PET/CT images were analyzed and histopathological findings (pelvic lymph node resection) served as the reference standard. Results: The median age of patients was 48 (range 22-86) years. 66% had squamous histotype. Median number of nodes dissected per patient was 21 (range 8-47), 2 of 47 patients had nodal metastases (4.25%). All patients in this group had no suspicious lymph nodes on 18F-FDG-PET/CT. Overall patient based sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 18F-FDG-PET/CT for detection of nodal disease were 0%, 100%, 0%, 96%, and 96% respectively. Conclusion: Pathologic validation of 18F-FDG-PET/CT imaging demonstrates little value for 18F-FDG-PET/CT in patients with early stage (FIGO stage 1a-1b1) MRI-defined lymph node negative cervical carcinoma. Since the likelihood of metastatic nodal disease is very low in women with stage 1a-1b1 cervical cancer, we believe that 18F-FDG-PET/CT should not have a role in the routine pre-treatment evaluation of these women. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Oncology |2 nationallicence | |
| 690 | 7 | |a Gynecology |2 nationallicence | |
| 690 | 7 | |a Cervical Cancer |2 nationallicence | |
| 690 | 7 | |a 18F-FDG-PET/CT |2 nationallicence | |
| 690 | 7 | |a MRI |2 nationallicence | |
| 700 | 1 | |a Driscoll |D Dearbhail |u St. James Hospital, Dublin 8, Dublin, Leinster, Ireland |4 aut | |
| 700 | 1 | |a Halpenny |D Darragh |u St. James Hospital, Dublin 8, Dublin, Leinster, Ireland |4 aut | |
| 700 | 1 | |a Johnston |D Ciaran |u St. James Hospital, Dublin 8, Dublin, Leinster, Ireland |4 aut | |
| 700 | 1 | |a Sheehy |D Niall |u St. James Hospital, Dublin 8, Dublin, Leinster, Ireland |4 aut | |
| 700 | 1 | |a Keogan |D Mary |u St. James Hospital, Dublin 8, Dublin, Leinster, Ireland |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/1(2015-01-01), 127-133 |x 0942-8925 |q 40:1<127 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-014-0194-x |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-014-0194-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Driscoll |D Dearbhail |u St. James Hospital, Dublin 8, Dublin, Leinster, Ireland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Halpenny |D Darragh |u St. James Hospital, Dublin 8, Dublin, Leinster, Ireland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Johnston |D Ciaran |u St. James Hospital, Dublin 8, Dublin, Leinster, Ireland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sheehy |D Niall |u St. James Hospital, Dublin 8, Dublin, Leinster, Ireland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Keogan |D Mary |u St. James Hospital, Dublin 8, Dublin, Leinster, Ireland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/1(2015-01-01), 127-133 |x 0942-8925 |q 40:1<127 |1 2015 |2 40 |o 261 | ||