caa a22 4500 605492034 CHVBK 20210128100513.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00261-014-0178-x doi (NATIONALLICENCE)springer-10.1007/s00261-014-0178-x Prospective evaluation of prior image constrained compressed sensing (PICCS) algorithm in abdominal CT: a comparison of reduced dose with standard dose imaging [Elektronische Daten] [Meghan Lubner, Perry Pickhardt, David Kim, Jie Tang, Alejandro del Rio, Guang-Hong Chen] Purpose: To prospectively study CT dose reduction using the "prior image constrained compressed sensing” (PICCS) reconstruction technique. Methods: Immediately following routine standard dose (SD) abdominal MDCT, 50 patients (mean age, 57.7years; mean BMI, 28.8) underwent a second reduced dose (RD) scan (targeted dose reduction, 70%-90%). DLP, CTDIvol, and SSDE were compared. Several reconstruction algorithms (FBP, ASIR, and PICCS) were applied to the RD series. SD images with FBP served as reference standard. Two blinded readers evaluated each series for subjective image quality and focal lesion detection. Results: Mean DLP, CTDIvol, and SSDE for RD series were 140.3mGycm (median 79.4), 3.7mGy (median 1.8), and 4.2mGy (median 2.3) compared with 493.7mGycm (median 345.8), 12.9mGy (median 7.9mGy), and 14.6mGy (median 10.1) for SD series, respectively. Mean effective patient diameter was 30.1cm (median 30), which translates to a mean SSDE reduction of 72% (P<0.001). RD-PICCS image quality score was 2.8±0.5, improved over the RD-FBP (1.7±0.7) and RD-ASIR (1.9±0.8) (P<0.001), but lower than SD (3.5±0.5) (P<0.001). Readers detected 81% (184/228) of focal lesions on RD-PICCS series, vs. 67% (153/228) and 65% (149/228) for RD-FBP and RD-ASIR, respectively. Mean image noise was significantly reduced on RD-PICCS series (13.9 HU) compared with RD-FBP (57.2) and RD-ASIR (44.1) (P<0.001). Conclusion: PICCS allows for marked dose reduction at abdominal CT with improved image quality and diagnostic performance over reduced dose FBP and ASIR. Further study is needed to determine indication-specific dose reduction levels that preserve acceptable diagnostic accuracy relative to higher dose protocols. Springer Science+Business Media New York, 2014 CT nationallicence Dose reduction nationallicence Iterative reconstruction nationallicence Lubner Meghan Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut Pickhardt Perry Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut Kim David Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut Tang Jie Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA aut del Rio Alejandro Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut Chen Guang-Hong Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 207-221 0942-8925 40:1<207 2015 40 261 https://doi.org/10.1007/s00261-014-0178-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0178-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lubner Meghan Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut NATIONALLICENCE 700 1- Pickhardt Perry Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut NATIONALLICENCE 700 1- Kim David Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut NATIONALLICENCE 700 1- Tang Jie Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA aut NATIONALLICENCE 700 1- del Rio Alejandro Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut NATIONALLICENCE 700 1- Chen Guang-Hong Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 207-221 0942-8925 40:1<207 2015 40 261