caa a22 4500 605492077 CHVBK 20210128100513.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00261-014-0185-y doi (NATIONALLICENCE)springer-10.1007/s00261-014-0185-y MRI for differentiation of renal cell carcinoma with sarcomatoid component from other renal tumor types [Elektronische Daten] [Mitsuru Takeuchi, Tatsuya Kawai, Tomohiro Suzuki, Taku Naiki, Noriyasu Kawai, Yukio Fujiyoshi, Hiroshi Inagaki, Kenjiro Kohri, Masaki Hara, Yuta Shibamoto] Purpose: To investigate the usefulness of MRI for detection of sarcomatoid renal cell carcinoma (SRCC) components within RCC and differentiation from other renal tumors. Methods: Two observers independently interpreted T2-weighted images of 10 patients with pathologically confirmed RCCs with SRCC and 131 with non-SRCC renal tumors, with special reference to conspicuously low signal intensity (SI) areas (T2LIA) compared to the renal cortex. SRCC probability was classified as (1) definitely non-SRCC, no T2LIA; (2) probably non-SRCC, <1cm T2LIA; (3) low probability of SRCC, homogeneous tumor with 1-3cm T2LIA; (4) probably SRCC, heterogeneous tumor with 1-3cm T2LIA; and (5) definitely SRCC, >3cm T2LIA, multiple >1cm T2LIAs, or showing disruption of the pseudocapsule. The observers used chemical shift imaging to exclude the area representing hemorrhage or hemosiderin deposition from T2LIA. Scores of 4/5 were regarded as positive for evaluating the accuracy and area under the receiver operating characteristic curve. The SI ratio of the lowest SI in the tumor to that of the renal cortex in the 1 and ≥2 score groups was compared using Mann-Whitney's U test. Results: Sensitivity, specificity, accuracy, and positive and negative predictive values were 90%, 95%, 94%, 56%, and 99%, respectively, and area under the receiver operating characteristic curve was 0.93. The mean SI ratio of the lowest SI in the tumor to that of the renal cortex was significantly lower in the ≥2 score group (0.58) than in the 1 score group (1.36). Conclusions: MRI predicted RCC with SRCC with a moderate positive predictive value and a high negative predictive value. Springer Science+Business Media New York, 2014 Carcinoma nationallicence Renal Cell nationallicence Sarcomatoid renal cell carcinoma nationallicence Magnetic resonance imaging nationallicence T2-weighted imaging nationallicence Diagnosis nationallicence Differential nationallicence Takeuchi Mitsuru Department of Radiology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Kawai Tatsuya Department of Radiology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Suzuki Tomohiro Department of Radiology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Naiki Taku Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Kawai Noriyasu Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Fujiyoshi Yukio Department of Clinical Pathology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Inagaki Hiroshi Department of Clinical Pathology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Kohri Kenjiro Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Hara Masaki Department of Radiology, Nagoya City West Medical Center, 1-1-1, hirade-cho, kita-ku, 462-8508, Nagoya, Japan aut Shibamoto Yuta Department of Radiology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 112-119 0942-8925 40:1<112 2015 40 261 https://doi.org/10.1007/s00261-014-0185-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0185-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takeuchi Mitsuru Department of Radiology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Kawai Tatsuya Department of Radiology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Suzuki Tomohiro Department of Radiology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Naiki Taku Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Kawai Noriyasu Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Fujiyoshi Yukio Department of Clinical Pathology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Inagaki Hiroshi Department of Clinical Pathology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Kohri Kenjiro Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Hara Masaki Department of Radiology, Nagoya City West Medical Center, 1-1-1, hirade-cho, kita-ku, 462-8508, Nagoya, Japan aut NATIONALLICENCE 700 1- Shibamoto Yuta Department of Radiology, Nagoya City University Graduate School of Medical Sciences and Medical school, 1 Kawasumi Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 112-119 0942-8925 40:1<112 2015 40 261