caa a22 4500 605492085 CHVBK 20210128100513.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00261-014-0188-8 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0188-8 Differentiation of small (≤2cm) hepatocellular carcinomas from small benign nodules in cirrhotic liver on gadoxetic acid-enhanced and diffusion-weighted magnetic resonance images [Elektronische Daten] [Heon-Ju Kwon, Jae Byun, Ji Kim, Gil-Sun Hong, Hyung Won, Yong Shin, Pyo Kim] Objective: To identify imaging characteristics that differentiate small (≤2cm) HCCs from small (≤2cm) benign nodules in cirrhotic liver on gadoxetic acid-enhanced and diffusion-weighted (DW) magnetic resonance (MR) images. Materials and methods: On gadoxetic acid-enhanced and DW MR images, we analysed signal intensity of 222 small HCCs and 61 benign nodules (diameter, 0.5-2cm) at each sequence and rim enhancement during portal or equilibrium phases. Univariate and multivariate logistic regression analyses identified predictors of HCC. Combinations of significant MR findings in multivariate analysis were compared with American Association for the Study of Liver Disease (AASLD) practice guidelines. Results: In multivariate analysis, arterial enhancement (adjusted odds ratio [aOR], 8.6), T2 hyperintensity (aOR, 5.8), and hyperintensity on DW images (aOR, 3.8) were significant for differentiating small HCCs from benign nodules (p≤0.004). When two or all three findings were applied as diagnostic criteria for differentiating small HCCs from benign nodules, sensitivity and accuracy were significantly higher compared with AASLD practice guidelines (91% vs. 78% and 89% vs. 81%, respectively; each p<0.0001). Conclusion: On gadoxetic acid-enhanced MR imaging, arterial enhancement and hyperintensity on T2-weighted and DW MR images are helpful for differentiating small HCCs from benign nodules in liver cirrhosis. Springer Science+Business Media New York, 2014 Hepatocellular carcinoma nationallicence Liver magnetic resonance image (MRI) nationallicence Gadoxetic acid nationallicence Diffusion-weighted MRI nationallicence American Association for the Study of Liver Disease (AASLD) guidelines nationallicence Kwon Heon-Ju Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-ku, 138-736, Seoul, Korea aut Byun Jae Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-ku, 138-736, Seoul, Korea aut Kim Ji Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-ku, 138-736, Seoul, Korea aut Hong Gil-Sun Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-ku, 138-736, Seoul, Korea aut Won Hyung Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-ku, 138-736, Seoul, Korea aut Shin Yong Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-ku, 138-736, Seoul, Korea aut Kim Pyo Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-ku, 138-736, Seoul, Korea aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 64-75 0942-8925 40:1<64 2015 40 261 https://doi.org/10.1007/s00261-014-0188-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0188-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kwon Heon-Ju Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-ku, 138-736, Seoul, Korea aut NATIONALLICENCE 700 1- Byun Jae Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-ku, 138-736, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Ji Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-ku, 138-736, Seoul, Korea aut NATIONALLICENCE 700 1- Hong Gil-Sun Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-ku, 138-736, Seoul, Korea aut NATIONALLICENCE 700 1- Won Hyung Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-ku, 138-736, Seoul, Korea aut NATIONALLICENCE 700 1- Shin Yong Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-ku, 138-736, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Pyo Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-ku, 138-736, Seoul, Korea aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 64-75 0942-8925 40:1<64 2015 40 261