Detection of prostate cancer with multiparametric MRI (mpMRI): effect of dedicated reader education on accuracy and confidence of index and anterior cancer diagnosis
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| 024 | 7 | 0 | |a 10.1007/s00261-014-0197-7 |2 doi |
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| 245 | 0 | 0 | |a Detection of prostate cancer with multiparametric MRI (mpMRI): effect of dedicated reader education on accuracy and confidence of index and anterior cancer diagnosis |h [Elektronische Daten] |c [Kirema Garcia-Reyes, Niccolò Passoni, Mark Palmeri, Christopher Kauffman, Kingshuk Choudhury, Thomas Polascik, Rajan Gupta] |
| 520 | 3 | |a Purpose: To evaluate the impact of dedicated reader education on accuracy/confidence of peripheral zone index cancer and anterior prostate cancer (PCa) diagnosis with mpMRI; secondary aim was to assess the ability of readers to differentiate low-grade cancer (Gleason 6 or below) from high-grade cancer (Gleason 7+). Materials and methods: Five blinded radiology fellows evaluated 31 total prostate mpMRIs in this IRB-approved, HIPAA-compliant, retrospective study for index lesion detection, confidence in lesion diagnosis (1-5 scale), and Gleason grade (Gleason 6 or lower vs. Gleason 7+). Following a dedicated education program, readers reinterpreted cases after a memory extinction period, blinded to initial reads. Reference standard was established combining whole mount histopathology with mpMRI findings by a board-certified radiologist with 5years of prostate mpMRI experience. Results: Index cancer detection: pre-education accuracy 74.2%; post-education accuracy 87.7% (p=0.003). Confidence in index lesion diagnosis: pre-education 4.22±1.04; post-education 3.75±1.41 (p=0.0004). Anterior PCa detection: pre-education accuracy 54.3%; post-education accuracy 94.3% (p=0.001). Confidence in anterior PCa diagnosis: pre-education 3.22±1.54; post-education 4.29±0.83 (p=0.0003). Gleason score accuracy: pre-education 54.8%; post-education 73.5% (p=0.0005). Conclusions: A dedicated reader education program on PCa detection with mpMRI was associated with a statistically significant increase in diagnostic accuracy of index cancer and anterior cancer detection as well as Gleason grade identification as compared to pre-education values. This was also associated with a significant increase in reader diagnostic confidence. This suggests that substantial interobserver variability in mpMRI interpretation can potentially be reduced with a focus on education and that this can occur over a fellowship training year. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Prostate cancer |2 nationallicence | |
| 690 | 7 | |a Multiparametric prostate MRI |2 nationallicence | |
| 690 | 7 | |a Reader education |2 nationallicence | |
| 700 | 1 | |a Garcia-Reyes |D Kirema |u Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA |4 aut | |
| 700 | 1 | |a Passoni |D Niccolò |u Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical Center, DUMC Box 2804, 27710, Durham, NC, USA |4 aut | |
| 700 | 1 | |a Palmeri |D Mark |u Department of Biomedical Engineering, Duke University, Room 258, Hudson Hall Annex, 27708, Durham, NC, USA |4 aut | |
| 700 | 1 | |a Kauffman |D Christopher |u Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA |4 aut | |
| 700 | 1 | |a Choudhury |D Kingshuk |u Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA |4 aut | |
| 700 | 1 | |a Polascik |D Thomas |u Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical Center, DUMC Box 2804, 27710, Durham, NC, USA |4 aut | |
| 700 | 1 | |a Gupta |D Rajan |u Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/1(2015-01-01), 134-142 |x 0942-8925 |q 40:1<134 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-014-0197-7 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-014-0197-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Garcia-Reyes |D Kirema |u Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Passoni |D Niccolò |u Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical Center, DUMC Box 2804, 27710, Durham, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Palmeri |D Mark |u Department of Biomedical Engineering, Duke University, Room 258, Hudson Hall Annex, 27708, Durham, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kauffman |D Christopher |u Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Choudhury |D Kingshuk |u Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Polascik |D Thomas |u Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical Center, DUMC Box 2804, 27710, Durham, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gupta |D Rajan |u Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/1(2015-01-01), 134-142 |x 0942-8925 |q 40:1<134 |1 2015 |2 40 |o 261 | ||