caa a22 4500 605492093 CHVBK 20210128100513.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00261-014-0197-7 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0197-7 Detection of prostate cancer with multiparametric MRI (mpMRI): effect of dedicated reader education on accuracy and confidence of index and anterior cancer diagnosis [Elektronische Daten] [Kirema Garcia-Reyes, Niccolò Passoni, Mark Palmeri, Christopher Kauffman, Kingshuk Choudhury, Thomas Polascik, Rajan Gupta] Purpose: To evaluate the impact of dedicated reader education on accuracy/confidence of peripheral zone index cancer and anterior prostate cancer (PCa) diagnosis with mpMRI; secondary aim was to assess the ability of readers to differentiate low-grade cancer (Gleason 6 or below) from high-grade cancer (Gleason 7+). Materials and methods: Five blinded radiology fellows evaluated 31 total prostate mpMRIs in this IRB-approved, HIPAA-compliant, retrospective study for index lesion detection, confidence in lesion diagnosis (1-5 scale), and Gleason grade (Gleason 6 or lower vs. Gleason 7+). Following a dedicated education program, readers reinterpreted cases after a memory extinction period, blinded to initial reads. Reference standard was established combining whole mount histopathology with mpMRI findings by a board-certified radiologist with 5years of prostate mpMRI experience. Results: Index cancer detection: pre-education accuracy 74.2%; post-education accuracy 87.7% (p=0.003). Confidence in index lesion diagnosis: pre-education 4.22±1.04; post-education 3.75±1.41 (p=0.0004). Anterior PCa detection: pre-education accuracy 54.3%; post-education accuracy 94.3% (p=0.001). Confidence in anterior PCa diagnosis: pre-education 3.22±1.54; post-education 4.29±0.83 (p=0.0003). Gleason score accuracy: pre-education 54.8%; post-education 73.5% (p=0.0005). Conclusions: A dedicated reader education program on PCa detection with mpMRI was associated with a statistically significant increase in diagnostic accuracy of index cancer and anterior cancer detection as well as Gleason grade identification as compared to pre-education values. This was also associated with a significant increase in reader diagnostic confidence. This suggests that substantial interobserver variability in mpMRI interpretation can potentially be reduced with a focus on education and that this can occur over a fellowship training year. Springer Science+Business Media New York, 2014 Prostate cancer nationallicence Multiparametric prostate MRI nationallicence Reader education nationallicence Garcia-Reyes Kirema Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA aut Passoni Niccolò Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical Center, DUMC Box 2804, 27710, Durham, NC, USA aut Palmeri Mark Department of Biomedical Engineering, Duke University, Room 258, Hudson Hall Annex, 27708, Durham, NC, USA aut Kauffman Christopher Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA aut Choudhury Kingshuk Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA aut Polascik Thomas Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical Center, DUMC Box 2804, 27710, Durham, NC, USA aut Gupta Rajan Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 134-142 0942-8925 40:1<134 2015 40 261 https://doi.org/10.1007/s00261-014-0197-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0197-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Garcia-Reyes Kirema Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Passoni Niccolò Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical Center, DUMC Box 2804, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Palmeri Mark Department of Biomedical Engineering, Duke University, Room 258, Hudson Hall Annex, 27708, Durham, NC, USA aut NATIONALLICENCE 700 1- Kauffman Christopher Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Choudhury Kingshuk Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Polascik Thomas Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical Center, DUMC Box 2804, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Gupta Rajan Department of Radiology, Duke University Medical Center, DUMC Box 3808, 27710, Durham, NC, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 134-142 0942-8925 40:1<134 2015 40 261