caa a22 4500 605492131 CHVBK 20210128100513.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00261-014-0196-8 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0196-8 Pancreatic adenocarcinoma: MRI conspicuity and pathologic correlations [Elektronische Daten] [Laurence Legrand, Véronique Duchatelle, Vincent Molinié, Isabelle Boulay-Coletta, Elodie Sibileau, Marc Zins] Purpose: To identify the MRI sequences producing the greatest pancreatic adenocarcinoma conspicuity and to assess correlations linking MRI signal intensity and apparent diffusion coefficient to histopathological findings. Methods: We retrospectively included 22 patients with pancreatic adenocarcinoma who underwent MRI (1.5 or 3T) before surgical resection. Fat-suppressed (FS) T1- and T2-weighted sequences; 3D FS dynamic T1-weighted gadolinium-enhanced gradient-echo (GRE) imaging at the arterial, portal, and delayed phases; and diffusion-weighted imaging (DWI) with b values of 600-800s/mm2 were reviewed. On each sequence, we assessed tumor conspicuity both qualitatively (3-point scale) and quantitatively (tumor-to-proximal and -distal pancreas contrast ratios), and we performed paired Wilcoxon tests to compare these data across sequences. We evaluated correlations between histopathological characteristics and MRI features. Results: 21/22 (95%) tumors were hypointense by 3D FS T1 GRE arterial phase imaging, which produced the greatest tumor conspicuity (p≤0.02). By DWI, 5/20 (25%) of tumors were isointense. The correlation between size by histology and MRI was strongest with DWI. A progressive enhancement pattern was associated with extensive and dense fibrous stroma (p≤0.03). Conclusions: 3D FS T1 GRE arterial phase imaging produces greater pancreatic adenocarcinoma conspicuity compared to DWI but underestimates tumor size. DWI provides the best size evaluation but fails to delineate the tumor in one-fourth of cases. Springer Science+Business Media New York, 2014 Pancreas nationallicence Adenocarcinoma nationallicence Magnetic resonance imaging nationallicence Diffusion-weighted imaging nationallicence Pathology nationallicence ADC : Apparent diffusion coefficient nationallicence DWI : Diffusion-weighted imaging nationallicence FRFSE : Fast-recovery fast spin echo nationallicence FS : Fat-suppressed nationallicence GRE : Gradient echo nationallicence ROI : Region of interest nationallicence SI : Signal intensity nationallicence Legrand Laurence Radiology Department, Fondation Hôpital Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France aut Duchatelle Véronique Pathology Department, Fondation Hôpital Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France aut Molinié Vincent Pathology Department, Fondation Hôpital Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France aut Boulay-Coletta Isabelle Radiology Department, Fondation Hôpital Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France aut Sibileau Elodie Radiology Department, Fondation Hôpital Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France aut Zins Marc Radiology Department, Fondation Hôpital Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 85-94 0942-8925 40:1<85 2015 40 261 https://doi.org/10.1007/s00261-014-0196-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0196-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Legrand Laurence Radiology Department, Fondation Hôpital Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France aut NATIONALLICENCE 700 1- Duchatelle Véronique Pathology Department, Fondation Hôpital Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France aut NATIONALLICENCE 700 1- Molinié Vincent Pathology Department, Fondation Hôpital Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France aut NATIONALLICENCE 700 1- Boulay-Coletta Isabelle Radiology Department, Fondation Hôpital Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France aut NATIONALLICENCE 700 1- Sibileau Elodie Radiology Department, Fondation Hôpital Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France aut NATIONALLICENCE 700 1- Zins Marc Radiology Department, Fondation Hôpital Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 85-94 0942-8925 40:1<85 2015 40 261