Visceral fat quantification in asymptomatic adults using abdominal CT: is it predictive of future cardiac events?
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| 005 | 20210128100513.0 | ||
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| 008 | 210128e20150101xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00261-014-0192-z |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-014-0192-z | ||
| 245 | 0 | 0 | |a Visceral fat quantification in asymptomatic adults using abdominal CT: is it predictive of future cardiac events? |h [Elektronische Daten] |c [Eva Ryckman, Ronald Summers, Jiamin Liu, Alejandro del Rio, Perry Pickhardt] |
| 520 | 3 | |a Purpose: The purpose of this study was to determine if quantifying visceral adipose tissue (VAT) at CT in asymptomatic adults can predict the likelihood of future cardiac events. Methods: Subcutaneous and visceral fat volumes were obtained from abdominal CT utilizing a validated semi-automated software tool in 663 asymptomatic adults (mean age 57.3years, 379F/284M) undergoing colorectal screening. Patients were followed for subsequent cardiac events, defined as myocardial infarction or coronary intervention for a mean follow-up interval of 7.0±1.4years. Relevant clinical data including Framingham risk score (FRS) were also collected. Statistical analysis included logistic regression, Pearson correlation coefficients, and Welch and Wilcoxon rank sum tests. Results: Cardiac events were documented in 32 subjects (4.8%) an average 3.0years after index CT. FRS was predictive of future cardiac events, signified by a higher score (mean score 11.9 vs. 7.4; p<0.001). HDL levels were significantly lower in the cardiac event cohort (mean 52.2 vs. 61.0; p<0.01). None of the other clinical variables were predictive and none of the CT-based fat measurements (visceral, subcutaneous, and total adipose tissue; visceral fat %) correlated with future cardiac events (p=0.561-0.886). Mean visceral fat % in the cardiac event cohort was 38.1% vs. 39.1% for the non-event group. Conclusion: Quantification of VAT at abdominal CT was not predictive of future cardiac events in this asymptomatic cohort, whereas HDL levels and FRSs correlated well with risk. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a CT |2 nationallicence | |
| 690 | 7 | |a Visceral fat |2 nationallicence | |
| 690 | 7 | |a Obesity |2 nationallicence | |
| 690 | 7 | |a Cardiovascular risk |2 nationallicence | |
| 690 | 7 | |a CT colonography screening |2 nationallicence | |
| 700 | 1 | |a Ryckman |D Eva |u Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, 53792-3252, Madison, WI, USA |4 aut | |
| 700 | 1 | |a Summers |D Ronald |u Imaging Biomarkers and Computer-aided Diagnosis Laboratory Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 20892-1182, Bethesda, MD, USA |4 aut | |
| 700 | 1 | |a Liu |D Jiamin |u Imaging Biomarkers and Computer-aided Diagnosis Laboratory Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 20892-1182, Bethesda, MD, USA |4 aut | |
| 700 | 1 | |a del Rio |D Alejandro |u Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, 53792-3252, Madison, WI, USA |4 aut | |
| 700 | 1 | |a Pickhardt |D Perry |u Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, 53792-3252, Madison, WI, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/1(2015-01-01), 222-226 |x 0942-8925 |q 40:1<222 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-014-0192-z |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-014-0192-z |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ryckman |D Eva |u Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, 53792-3252, Madison, WI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Summers |D Ronald |u Imaging Biomarkers and Computer-aided Diagnosis Laboratory Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 20892-1182, Bethesda, MD, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liu |D Jiamin |u Imaging Biomarkers and Computer-aided Diagnosis Laboratory Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 20892-1182, Bethesda, MD, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a del Rio |D Alejandro |u Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, 53792-3252, Madison, WI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pickhardt |D Perry |u Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, 53792-3252, Madison, WI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/1(2015-01-01), 222-226 |x 0942-8925 |q 40:1<222 |1 2015 |2 40 |o 261 | ||