caa a22 4500 605492158 CHVBK 20210128100513.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00261-014-0192-z doi (NATIONALLICENCE)springer-10.1007/s00261-014-0192-z Visceral fat quantification in asymptomatic adults using abdominal CT: is it predictive of future cardiac events? [Elektronische Daten] [Eva Ryckman, Ronald Summers, Jiamin Liu, Alejandro del Rio, Perry Pickhardt] Purpose: The purpose of this study was to determine if quantifying visceral adipose tissue (VAT) at CT in asymptomatic adults can predict the likelihood of future cardiac events. Methods: Subcutaneous and visceral fat volumes were obtained from abdominal CT utilizing a validated semi-automated software tool in 663 asymptomatic adults (mean age 57.3years, 379F/284M) undergoing colorectal screening. Patients were followed for subsequent cardiac events, defined as myocardial infarction or coronary intervention for a mean follow-up interval of 7.0±1.4years. Relevant clinical data including Framingham risk score (FRS) were also collected. Statistical analysis included logistic regression, Pearson correlation coefficients, and Welch and Wilcoxon rank sum tests. Results: Cardiac events were documented in 32 subjects (4.8%) an average 3.0years after index CT. FRS was predictive of future cardiac events, signified by a higher score (mean score 11.9 vs. 7.4; p<0.001). HDL levels were significantly lower in the cardiac event cohort (mean 52.2 vs. 61.0; p<0.01). None of the other clinical variables were predictive and none of the CT-based fat measurements (visceral, subcutaneous, and total adipose tissue; visceral fat %) correlated with future cardiac events (p=0.561-0.886). Mean visceral fat % in the cardiac event cohort was 38.1% vs. 39.1% for the non-event group. Conclusion: Quantification of VAT at abdominal CT was not predictive of future cardiac events in this asymptomatic cohort, whereas HDL levels and FRSs correlated well with risk. Springer Science+Business Media New York, 2014 CT nationallicence Visceral fat nationallicence Obesity nationallicence Cardiovascular risk nationallicence CT colonography screening nationallicence Ryckman Eva Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut Summers Ronald Imaging Biomarkers and Computer-aided Diagnosis Laboratory Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 20892-1182, Bethesda, MD, USA aut Liu Jiamin Imaging Biomarkers and Computer-aided Diagnosis Laboratory Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 20892-1182, Bethesda, MD, USA aut del Rio Alejandro Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut Pickhardt Perry Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 222-226 0942-8925 40:1<222 2015 40 261 https://doi.org/10.1007/s00261-014-0192-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0192-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ryckman Eva Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut NATIONALLICENCE 700 1- Summers Ronald Imaging Biomarkers and Computer-aided Diagnosis Laboratory Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 20892-1182, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Liu Jiamin Imaging Biomarkers and Computer-aided Diagnosis Laboratory Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 20892-1182, Bethesda, MD, USA aut NATIONALLICENCE 700 1- del Rio Alejandro Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut NATIONALLICENCE 700 1- Pickhardt Perry Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, 53792-3252, Madison, WI, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/1(2015-01-01), 222-226 0942-8925 40:1<222 2015 40 261