caa a22 4500 605492271 CHVBK 20210128100514.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00261-015-0379-y doi (NATIONALLICENCE)springer-10.1007/s00261-015-0379-y Dynamic enhancement pattern of intrahepatic cholangiocarcinoma on contrast-enhanced ultrasound: the correlation with cirrhosis and tumor size [Elektronische Daten] [Qing Lu, Li-Yun Xue, Wen-Ping Wang, Bei-Jian Huang, Cui-Xian Li] Purpose: To retrospectively evaluate the dynamic enhancement pattern of contrast-enhanced ultrasound (CEUS) in intrahepatic cholangiocarcinoma (ICC) of varying sizes and hepatic backgrounds. Materials and methods: CEUS was performed in 98 pathologically confirmed ICCs (n=39<30mm, n=59>30mm; n=45 with cirrhosis and n=53 with normal liver). The dynamic enhancement pattern of CEUS was retrospectively analyzed. Results: In the arterial phase, heterogeneous hyper-enhancement was more frequent in ICCs with cirrhosis (21/45, 46.7% vs. 11/53, 20.8% in ICCs with normal liver, p=0.009), while peripheral hyper-enhancement and hypo-enhancement were more common in ICCs with normal liver (14/53, 26.4%; 11/53, 20.8% vs. 2/45, 4.4%; 2/45, 4.4% in ICCs with cirrhosis, p=0.005 and 0.033, respectively). There were no significant differences between portal and delayed phases. In ICCs<30mm, homogeneous hyper-enhancement was more frequently identified (27/39, 69.2% vs. 10/59, 16.9% in ICCs>30mm, p<0.001), whereas in ICCs>30mm, heterogeneous, and peripheral hyper-enhancement were more commonly observed (26/59, 44.1% vs. 6/39, 15.4% in ICCs<30mm, p=0.004, and 14/59, 23.7% vs. 2/39, 5.1% in ICCs<30mm, p=0.023, respectively). The washout pattern in portal and delayed phases were not significantly different in ICCs with different sizes. 60.7% (17/28) ICCs<30mm and 85.2% (23/27) ICCs>30mm with cirrhosis, together with 66.7% (14/21) ICCs<30mm with normal liver displayed intense contrast agent uptake (homogeneous or heterogeneous hyper-enhancement) in arterial phase followed by washout in portal and delayed phase, which was much higher than that in ICCs>30mm with normal liver (34.4%, 11/32, p<0.001, <0.001 and =0.027, respectively). Conclusion: The CEUS dynamic enhancement pattern of ICC varies with size and hepatic background. The enhancement pattern is indistinguishable from hepatocellular carcinoma on CEUS in most ICCs with cirrhosis and in most ICCs<30mm with normal liver. Springer Science+Business Media New York, 2015 Intrahepatic cholangiocarcinoma nationallicence Ultrasound nationallicence Contrast agent nationallicence Cirrhosis nationallicence Lu Qing Department of Ultrasound, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, 200032, Shanghai, China aut Xue Li-Yun Department of Ultrasound, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, 200032, Shanghai, China aut Wang Wen-Ping Department of Ultrasound, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, 200032, Shanghai, China aut Huang Bei-Jian Department of Ultrasound, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, 200032, Shanghai, China aut Li Cui-Xian Department of Ultrasound, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, 200032, Shanghai, China aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1558-1566 0942-8925 40:6<1558 2015 40 261 https://doi.org/10.1007/s00261-015-0379-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0379-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lu Qing Department of Ultrasound, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, 200032, Shanghai, China aut NATIONALLICENCE 700 1- Xue Li-Yun Department of Ultrasound, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, 200032, Shanghai, China aut NATIONALLICENCE 700 1- Wang Wen-Ping Department of Ultrasound, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, 200032, Shanghai, China aut NATIONALLICENCE 700 1- Huang Bei-Jian Department of Ultrasound, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, 200032, Shanghai, China aut NATIONALLICENCE 700 1- Li Cui-Xian Department of Ultrasound, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, 200032, Shanghai, China aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1558-1566 0942-8925 40:6<1558 2015 40 261