caa a22 4500 60549231X CHVBK 20210128100514.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00261-014-0328-1 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0328-1 Retrospective cohort study of portacaval lymphadenopathy identified on multidetector CT and implications for follow-up [Elektronische Daten] [Veena Iyer, Sandeep Hedgire, Sumedh Hoskote, David Borczuk, Mukesh Harisinghani] Purpose: Portacaval lymphadenopathy (PCLA) is common in cirrhosis and chronic viral hepatitis and is frequently an incidental finding on abdominal CT scans. We aimed to detect the incidence of malignancy in organs drained by portacaval nodes in patients with PCLA associated with cirrhosis or chronic viral hepatitis, or incidentally detected PCLA. Methods: We searched CT reports from 2005 to 2007 for the phrases "periportal node” and "portacaval node.” MDCTs of patients with portacaval nodes ≥10mm in maximal short-axis size on contrast-enhanced MDCTs, were included. Records were reviewed for presence of malignancy, liver metastases, chronic viral hepatitis, and cirrhosis. Clinical or imaging follow-up ≥6months was performed to detect if malignancy developed in organs drained by portacaval nodes in patients with incidental PCLA, cirrhosis, or chronic viral hepatitis. Results: 479 patients met inclusion criteria [298 males (62%), mean age 61.4years]. In 285 (59.5%) patients, PCLA was explained by local pathology or systemic lymphadenopathy. PCLA was incidental in 146 (30.5%) patients. Of these, 112 (76.7%) had ≥6months of follow-up (median 26months). No patient with incidental PCLA developed malignancy in organs drained by these nodes. Cirrhosis or chronic viral hepatitis was present in 48 (10.0%) patients. Of these, 42 (87.5%) had ≥6months follow-up (median 28months), and only 1 patient developed cholangiocarcinoma (positive predictive value 2.4%). Conclusions: Development of malignancy is rare in patients with PCLA, either incidental or secondary to cirrhosis or chronic viral hepatitis. Our study suggests that no follow-up of PCLA is required in these settings. Springer Science+Business Media New York, 2014 Portacaval lymph nodes nationallicence Cirrhosis nationallicence Viral hepatitis nationallicence Incidental lymphadenopathy nationallicence Iyer Veena Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut Hedgire Sandeep Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut Hoskote Sumedh Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Borczuk David Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut Harisinghani Mukesh Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1481-1486 0942-8925 40:6<1481 2015 40 261 https://doi.org/10.1007/s00261-014-0328-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0328-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Iyer Veena Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Hedgire Sandeep Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Hoskote Sumedh Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Borczuk David Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Harisinghani Mukesh Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1481-1486 0942-8925 40:6<1481 2015 40 261