Can volumetric ADC measurement help predict response to Y90 radioembolization in HCC?
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| 024 | 7 | 0 | |a 10.1007/s00261-014-0295-6 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-014-0295-6 | ||
| 245 | 0 | 0 | |a Can volumetric ADC measurement help predict response to Y90 radioembolization in HCC? |h [Elektronische Daten] |c [Michael Vouche, Riad Salem, Robert Lewandowski, Frank Miller] |
| 520 | 3 | |a Aim: To compare changes in RECIST, anatomical volume, mRECIST, and volumetric diffusion-weighted Imaging parameters (3D apparent diffusion coefficient (ADC) measurements), with pathological analysis of hepatocellular carcinoma (HCC) treated by 90Yttrium radioembolization (Y90). Methods: 21 patients were treated by Y90 as a sole treatment modality for solitary, >2cm HCC that underwent liver transplantation. MRI at baseline, 1 and 3months post-Y90, and tumor pathological findings on explants were reviewed in all patients. Results: Compared to baseline (RECIST/volume: 3.6cm/17.7cm3), RECIST and volume were not modified after Y90 (1month, p=0.28/0.09 RECIST/tumor volume; 3months, p=0.28/0.54). In contrast, mRECIST (3.3-1.4cm, p<0.001), mean ADC (0.185-1.093mm2/s×10−3, p=0.04), and ADC standard deviation (STD) (0.041-0.201mm2/s×10−3, p=0.0496) changed as earlier as 1month post-Y90. ADC STD % change was higher in ADC responding lesions than non-responding lesions at 1month (p=0.002) and 3months (p=0.008). All lesions exhibited necrosis on pathological analysis (11 partially viable, 10 complete pathological necrosis (CPN)) but no imaging criterion was able to predict CPN. mRECIST (±ADC) at 1 (κ±ADC=0.08/0.06) or 3months (κ=−0.06/−0.06) were poor predictors of pathological response. Conclusion: As soon as 1month post-treatment, mRECIST and volumetric ADC performed better than traditional size RECIST or volumetric parameters in detecting imaging response to Y90; however, CPN cannot be predicted by any criteria. Improvements in methodologies to assess response and identification of better surrogates are awaited. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Hepatocellular carcinoma |2 nationallicence | |
| 690 | 7 | |a Radioembolization |2 nationallicence | |
| 690 | 7 | |a Yttrium-90 |2 nationallicence | |
| 690 | 7 | |a Response assessment |2 nationallicence | |
| 690 | 7 | |a ADC |2 nationallicence | |
| 690 | 7 | |a ADC : Apparent diffusion coefficient |2 nationallicence | |
| 690 | 7 | |a cTACE : Conventional transarterial chemoembolization |2 nationallicence | |
| 690 | 7 | |a CPN : Complete pathological necrosis |2 nationallicence | |
| 690 | 7 | |a DWI : Diffusion-weighted imaging |2 nationallicence | |
| 690 | 7 | |a GRE : Gradient echo |2 nationallicence | |
| 690 | 7 | |a (m)RECIST : (Modified) response criteria in solid tumors |2 nationallicence | |
| 690 | 7 | |a MRI : Magnetic resonance imaging |2 nationallicence | |
| 690 | 7 | |a IQR : Interquartile range |2 nationallicence | |
| 690 | 7 | |a 99Tc-MAA : 99Technetium-macroaggregated albumin |2 nationallicence | |
| 690 | 7 | |a STD : Standard deviation |2 nationallicence | |
| 690 | 7 | |a Y90 : 90Yttrium radioembolization |2 nationallicence | |
| 700 | 1 | |a Vouche |D Michael |u Section of Interventional Radiology and Division of Interventional Oncology, Department of Radiology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA |4 aut | |
| 700 | 1 | |a Salem |D Riad |u Section of Interventional Radiology and Division of Interventional Oncology, Department of Radiology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA |4 aut | |
| 700 | 1 | |a Lewandowski |D Robert |u Section of Interventional Radiology and Division of Interventional Oncology, Department of Radiology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA |4 aut | |
| 700 | 1 | |a Miller |D Frank |u Department of Radiology, Feinberg School of Medicine, Northwestern Memorial Hospital, Northwestern University, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1471-1480 |x 0942-8925 |q 40:6<1471 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-014-0295-6 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-014-0295-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vouche |D Michael |u Section of Interventional Radiology and Division of Interventional Oncology, Department of Radiology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Salem |D Riad |u Section of Interventional Radiology and Division of Interventional Oncology, Department of Radiology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lewandowski |D Robert |u Section of Interventional Radiology and Division of Interventional Oncology, Department of Radiology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Miller |D Frank |u Department of Radiology, Feinberg School of Medicine, Northwestern Memorial Hospital, Northwestern University, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1471-1480 |x 0942-8925 |q 40:6<1471 |1 2015 |2 40 |o 261 | ||