MDCT of extranodal mantle cell lymphoma: a single institute experience
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| 024 | 7 | 0 | |a 10.1007/s00261-015-0389-9 |2 doi |
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| 245 | 0 | 0 | |a MDCT of extranodal mantle cell lymphoma: a single institute experience |h [Elektronische Daten] |c [Akshay Baheti, Sree Tirumani, Rani Sewatkar, Saboo Sachin, Atul Shinagare, Nikhil Ramaiya] |
| 520 | 3 | |a Objective: To study the pattern of extranodal and particularly gastrointestinal (GI) involvement of mantle cell lymphoma (MCL) on MDCT Materials and methods: In this IRB-approved, HIPAA compliant retrospective study, MDCT features of 78 patients (62 males and 16 females, mean age 57years) with MCL including 28 patients at presentation were reviewed. Clinical and histopathological (blastoid vs. non-blastoid) data were noted from medical records. Results: Extranodal involvement was present in overall 51/78 patients on CT (65%), 18/28 (64%) patients at presentation. Spleen (21/78-27%) and bowel (19/78-24%) were the most common sites of extranodal involvement by MCL on imaging, followed by lungs (10/78-13%) and skin/subcutaneous tissue (9/78-12%). Bowel involvement was either in the form of endophytic polypoidal lesions (n=11, mean size 3.1cm), as focal mild bowel wall thickening (n=5, mean thickness 1.4cm), or as combination of the two (n=3). Blastoid histology was present in 14/78 (24%) patients and was statistically associated with skin/subcutaneous involvement (p<0.05; Fisher's exact t test). Median follow-up was 72months during which 21 patients died with median survival of 48months (26months for blastoid histology vs. 47months for non-blastoid histology). There was no statistical correlation between sites of involvement and survival. Conclusions: MCL has a predilection for extranodal disease, predominantly involving the spleen, bowel, lungs, and subcutaneous tissue. GI involvement on CT is in the form of endoluminal polypoidal lesions and mild bowel wall thickening. Skin/subcutaneous involvement was statistically more common with blastoid histology in our study. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Mantle cell lymphoma |2 nationallicence | |
| 690 | 7 | |a Extranodal |2 nationallicence | |
| 690 | 7 | |a Gastrointestinal |2 nationallicence | |
| 690 | 7 | |a GI |2 nationallicence | |
| 690 | 7 | |a CT |2 nationallicence | |
| 700 | 1 | |a Baheti |D Akshay |u Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, 02215, Boston, MA, USA |4 aut | |
| 700 | 1 | |a Tirumani |D Sree |u Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, 02215, Boston, MA, USA |4 aut | |
| 700 | 1 | |a Sewatkar |D Rani |u Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, 02115, Boston, MA, USA |4 aut | |
| 700 | 1 | |a Sachin |D Saboo |u Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, 02215, Boston, MA, USA |4 aut | |
| 700 | 1 | |a Shinagare |D Atul |u Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, 02215, Boston, MA, USA |4 aut | |
| 700 | 1 | |a Ramaiya |D Nikhil |u Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, 02215, Boston, MA, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1693-1699 |x 0942-8925 |q 40:6<1693 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-015-0389-9 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-015-0389-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Baheti |D Akshay |u Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, 02215, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tirumani |D Sree |u Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, 02215, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sewatkar |D Rani |u Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, 02115, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sachin |D Saboo |u Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, 02215, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shinagare |D Atul |u Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, 02215, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ramaiya |D Nikhil |u Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, 02215, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1693-1699 |x 0942-8925 |q 40:6<1693 |1 2015 |2 40 |o 261 | ||