caa a22 4500 605492484 CHVBK 20210128100515.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00261-015-0395-y doi (NATIONALLICENCE)springer-10.1007/s00261-015-0395-y Quantitative T2* magnetic resonance imaging for renal iron overload assessment: normal values by age and sex [Elektronische Daten] [Emanuele Grassedonio, Antonella Meloni, Vincenzo Positano, Daniele De Marchi, Patrizia Toia, Massimo Midiri, Alessia Pepe] Purpose: Few studies of renal iron content have been performed with multiecho gradient-echo (ME-GRE) T2* magnetic resonance imaging (MRI). We assessed the feasibility and reproducibility of ME-GRE T2* MRI for measuring regional and global renal T2* values, and established the lower limits of normal in healthy subjects, also correlating the measured values with age and sex. Methods: Twenty consecutive healthy subjects (13 men and 7 women, mean age 29.1±7.2years, range 19-42years) underwent MRI examinations using a 1.5 T magnet and an ME-GRE T2* sequence. For each kidney, T2* was measured in anterior, posterolateral, and posteromedial renal parenchymal regions. The mean T2* value was calculated as the average of the two kidneys T2* values. Results: For the mean kidney T2* value, the coefficients of variation for intra- and inter-operator reproducibility were 1.76% and 6.23%, respectively. The lower limit of normal for the mean kidney T2* value was 31ms (median 51.39±10.09). There was no significant difference between left and right kidney T2* values (p=0.578). No significant correlation was found between T2* values and subjects' age or sex. Conclusions: Renal ME-GRE T2* appears to be a feasible and reproducible technique. The renal T2* values showed no dependence on sex or age. Springer Science+Business Media New York, 2015 Multiecho T2* nationallicence Iron loading nationallicence Kidney nationallicence Thalassemia nationallicence Grassedonio Emanuele Istituto di Radiologia, DIBIMED, University of Palermo, Palermo, Italy aut Meloni Antonella CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut Positano Vincenzo Technologies Department, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy aut De Marchi Daniele CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut Toia Patrizia Istituto di Radiologia, DIBIMED, University of Palermo, Palermo, Italy aut Midiri Massimo Istituto di Radiologia, DIBIMED, University of Palermo, Palermo, Italy aut Pepe Alessia CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1700-1704 0942-8925 40:6<1700 2015 40 261 https://doi.org/10.1007/s00261-015-0395-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0395-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grassedonio Emanuele Istituto di Radiologia, DIBIMED, University of Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Meloni Antonella CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut NATIONALLICENCE 700 1- Positano Vincenzo Technologies Department, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy aut NATIONALLICENCE 700 1- De Marchi Daniele CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut NATIONALLICENCE 700 1- Toia Patrizia Istituto di Radiologia, DIBIMED, University of Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Midiri Massimo Istituto di Radiologia, DIBIMED, University of Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Pepe Alessia CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1700-1704 0942-8925 40:6<1700 2015 40 261