Histotype differentiation of hypo-echoic renal tumors on CEUS: usefulness of enhancement homogeneity and intensity
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 605492522 | ||
| 003 | CHVBK | ||
| 005 | 20210128100515.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150801xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00261-014-0340-5 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-014-0340-5 | ||
| 245 | 0 | 0 | |a Histotype differentiation of hypo-echoic renal tumors on CEUS: usefulness of enhancement homogeneity and intensity |h [Elektronische Daten] |c [Qing Lu, Li-yun Xue, Bei-jian Huang, Wen-ping Wang, Cui-xian Li] |
| 520 | 3 | |a Purpose: The purpose of this study is to evaluate qualitative and quantitative analysis of contrast-enhanced ultrasound (CEUS) in differential diagnoses of hypo-echoic renal tumor histotypes. Methods: Our study cohort comprised 103 clear cell renal cell carcinomas (ccRCCs), 24 papillary renal cell carcinomas (pRCCs), 28 chromophobe renal cell carcinomas (cRCCs), and 34 angiomyolipomas (AMLs), hypo-echoic on ultrasound, and imaged between January 2011 and December 2013. Enhancement homogeneity and tumor-to-cortex intensity ratio (TOC ratio) were retrospectively analyzed. Results: Overall, heterogeneous enhancement was more common in ccRCCs than AMLs, pRCCs, and cRCCs. TOC ratio showed the trend ccRCC>AML>pRCC=cRCC. Similar trends were seen in tumors <4cm. Using heterogeneous enhancement or TOC ratio >107.5% to differentiate ccRCC from other histotypes, the sensitivity, specificity, positive and negative predictive values were 93.1%, 74.5%, 84.8%, and 87.5%, respectively. Tumors >4cm exhibited considerable overlap in enhancement homogeneity among different histotypes. TOC ratios were similar between homo- and heterogeneously enhancing tumors for ccRCCs and for pRCCs and cRCCs, but higher in homogeneously enhancing than heterogeneously enhancing AMLs. In homo- and heterogeneously enhancing tumors, TOC ratios followed the trends ccRCCs>AMLs>pRCCs=cRCCs and ccRCCs>AMLs=pRCCs=cRCCs, respectively. With TOC ratio >105.81% and >72.37% to differentiate homo- and heterogeneously enhancing ccRCCs from other histotypes in tumors >4cm with same enhancement homogeneity, the sensitivity, specificity, positive and negative predictive values were 70.0%, 85.7%, 70.0%, 85.7%, and 91.7%, 94.4%, 95.7%, 89.5%, respectively. Conclusion: CEUS homogeneity and TOC ratio are helpful in differential diagnosis of hypo-echoic renal tumor histotypes. Diameter and enhancement homogeneity should be considered when deciding the diagnostic TOC ratio cutoff. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Histotype |2 nationallicence | |
| 690 | 7 | |a Renal tumor |2 nationallicence | |
| 690 | 7 | |a Contrast-enhanced ultrasound |2 nationallicence | |
| 690 | 7 | |a Quantitative analysis |2 nationallicence | |
| 700 | 1 | |a Lu |D Qing |u Department of Ultrasound, Shanghai Medical Imaging Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, 200032, Shanghai, China |4 aut | |
| 700 | 1 | |a Xue |D Li-yun |u Department of Ultrasound, Shanghai Medical Imaging Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, 200032, Shanghai, China |4 aut | |
| 700 | 1 | |a Huang |D Bei-jian |u Department of Ultrasound, Shanghai Medical Imaging Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, 200032, Shanghai, China |4 aut | |
| 700 | 1 | |a Wang |D Wen-ping |u Department of Ultrasound, Shanghai Medical Imaging Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, 200032, Shanghai, China |4 aut | |
| 700 | 1 | |a Li |D Cui-xian |u Department of Ultrasound, Shanghai Medical Imaging Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, 200032, Shanghai, China |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1675-1683 |x 0942-8925 |q 40:6<1675 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-014-0340-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-014-0340-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lu |D Qing |u Department of Ultrasound, Shanghai Medical Imaging Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, 200032, Shanghai, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Xue |D Li-yun |u Department of Ultrasound, Shanghai Medical Imaging Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, 200032, Shanghai, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Huang |D Bei-jian |u Department of Ultrasound, Shanghai Medical Imaging Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, 200032, Shanghai, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wang |D Wen-ping |u Department of Ultrasound, Shanghai Medical Imaging Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, 200032, Shanghai, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Li |D Cui-xian |u Department of Ultrasound, Shanghai Medical Imaging Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, 200032, Shanghai, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1675-1683 |x 0942-8925 |q 40:6<1675 |1 2015 |2 40 |o 261 | ||