caa a22 4500 605492611 CHVBK 20210128100516.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00261-014-0332-5 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0332-5 Enhancement of radiofrequency ablation of the liver combined with transarterial embolization using various embolic agents [Elektronische Daten] [Kuniyasu Irie, Manabu Morimoto, Kazushi Numata, Masaaki Kondo, Satoshi Moriya, Yu Shimoyama, Akito Nozaki, Yoshihiro Goda, Satoshi Kobayashi, Makoto Ueno, Shinichi Ohkawa, Katsuaki Tanaka, Shin Maeda] Purpose: Reducing blood flow in the liver during radiofrequency ablation causes enlargement of the ablation area. In this animal study, we evaluated the extended effects of radiofrequency ablation combined with transarterial embolization using various embolic agents. Methods: We treated 38 radiofrequency ablation lesions after embolization in 13 pigs using the following embolic agents: gelatin sponge (Group A); iodized oil followed by gelatin sponge (Group B); 700-900µm calibrated microspheres (Group C); and 100-300µm calibrated microspheres (Group D). Lesion size and pathological evaluations of these ablation lesions were compared with those receiving radiofrequency ablation alone (control). Results: Both the long- and short-axis diameters of the ablation lesions for Groups A, B, C, and D were significantly longer than those of controls (long axis/short axis for Groups A, B, C, D, and controls were 27.2/23.2, 30.2/26.0, 28.2/22.2, 32.0/24.4, and 23.2mm/18.5mm, respectively) (P<0.05). The long-axis of the ablation lesion for Group D was significantly longer than those for both Groups A and C (P<0.05). At pathological examination, the central ablation lesions showed coagulative necrosis with a surrounding hemorrhagic rim, and the microspheres were fitted to occlude the small arteries in peripheral liver parenchyma in Groups C and D. Conclusions: The extended effects of embolization with small microspheres may be stronger than those with large microspheres and were equal to those with iodized oil followed by gelatin sponge. Springer Science+Business Media New York, 2014 Radiofrequency nationallicence Embolization nationallicence Microspheres nationallicence Hepatocellular carcinoma nationallicence Coagulation nationallicence Combination nationallicence Irie Kuniyasu Department of Hepatobiliary and Pancreatic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan aut Morimoto Manabu Department of Hepatobiliary and Pancreatic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan aut Numata Kazushi Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan aut Kondo Masaaki Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan aut Moriya Satoshi Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan aut Shimoyama Yu Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan aut Nozaki Akito Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan aut Goda Yoshihiro Department of Hepatobiliary and Pancreatic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan aut Kobayashi Satoshi Department of Hepatobiliary and Pancreatic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan aut Ueno Makoto Department of Hepatobiliary and Pancreatic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan aut Ohkawa Shinichi Department of Hepatobiliary and Pancreatic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan aut Tanaka Katsuaki Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan aut Maeda Shin Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1821-1828 0942-8925 40:6<1821 2015 40 261 https://doi.org/10.1007/s00261-014-0332-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0332-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Irie Kuniyasu Department of Hepatobiliary and Pancreatic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan aut NATIONALLICENCE 700 1- Morimoto Manabu Department of Hepatobiliary and Pancreatic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan aut NATIONALLICENCE 700 1- Numata Kazushi Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan aut NATIONALLICENCE 700 1- Kondo Masaaki Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan aut NATIONALLICENCE 700 1- Moriya Satoshi Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan aut NATIONALLICENCE 700 1- Shimoyama Yu Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan aut NATIONALLICENCE 700 1- Nozaki Akito Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan aut NATIONALLICENCE 700 1- Goda Yoshihiro Department of Hepatobiliary and Pancreatic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan aut NATIONALLICENCE 700 1- Kobayashi Satoshi Department of Hepatobiliary and Pancreatic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan aut NATIONALLICENCE 700 1- Ueno Makoto Department of Hepatobiliary and Pancreatic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan aut NATIONALLICENCE 700 1- Ohkawa Shinichi Department of Hepatobiliary and Pancreatic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan aut NATIONALLICENCE 700 1- Tanaka Katsuaki Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan aut NATIONALLICENCE 700 1- Maeda Shin Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1821-1828 0942-8925 40:6<1821 2015 40 261