caa a22 4500 605492662 CHVBK 20210128100516.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00261-014-0345-0 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0345-0 Value of bimodal 18F-choline-PET/MRI and trimodal 18F-choline-PET/MRI/TRUS for the assessment of prostate cancer recurrence after radiation therapy and radical prostatectomy [Elektronische Daten] [Francesco Paparo, Arnoldo Piccardo, Lorenzo Bacigalupo, Andrea Romagnoli, Riccardo Piccazzo, Michela Monticone, Luca Cevasco, Fabio Campodonico, Giuseppe Conzi, Giorgio Carmignani, Gian Rollandi] Between 27% and 53% of all patients who undergo radical prostatectomy (RP) or radiation therapy (RT) as the first-line treatment of prostate cancer (PCa) develop a biochemical recurrence. Imaging plays a pivotal role in restaging by helping to distinguish between local relapse and metastatic disease (i.e., lymph-node and skeletal metastases). At present, the most promising tools for assessing PCa patients with biochemical recurrence are multiparametric magnetic resonance imaging (mpMRI) and positron emission tomography (PET)/computed tomography (CT) with radio-labeled choline derivatives. The main advantage of mpMRI is its high diagnostic accuracy in detecting local recurrence, while choline-PET/CT is able to identify lymph-node metastases when they are not suspicious on morphological imaging. The most recent advances in the field of fusion imaging have shown that multimodal co-registration, synchronized navigation, and combined interpretation are more valuable than the individual; separate assessment offered by different diagnostic techniques. The objective of the present essay was to describe the value of bimodal choline-PET/mpMRI fusion imaging and trimodal choline-PET/mpMRI/transrectal ultrasound (TRUS) in the assessment of PCa recurrence after RP and RT. Bimodal choline-PET/mpMRI fusion imaging allows morphological, functional, and metabolic information to be combined, thereby overcoming the limitations of each separate imaging modality. In addition, trimodal real-time choline-PET/mpMRI/TRUS fusion imaging may be useful for the planning and real-time guidance of biopsy procedures in order to obtain histological confirmation of the local recurrence. Springer Science+Business Media New York, 2015 Fusion imaging nationallicence Prostate cancer nationallicence Magnetic resonance imaging nationallicence Choline nationallicence Positron emission tomography nationallicence Transrectal ultrasound nationallicence Paparo Francesco Unit of Radiology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut Piccardo Arnoldo Nuclear Medicine Unit, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut Bacigalupo Lorenzo Unit of Radiology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut Romagnoli Andrea Unit of Urology, IRCCS Azienda Ospedaliera Universitaria San Martino - IST, University of Genoa, Via Leon Battista Alberti 4, 16132, Genoa, Italy aut Piccazzo Riccardo Unit of Radiology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut Monticone Michela Unit of Urology, IRCCS Azienda Ospedaliera Universitaria San Martino - IST, University of Genoa, Via Leon Battista Alberti 4, 16132, Genoa, Italy aut Cevasco Luca Unit of Radiology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut Campodonico Fabio Unit of Urology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut Conzi Giuseppe Unit of Urology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut Carmignani Giorgio Unit of Urology, IRCCS Azienda Ospedaliera Universitaria San Martino - IST, University of Genoa, Via Leon Battista Alberti 4, 16132, Genoa, Italy aut Rollandi Gian Unit of Radiology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1772-1787 0942-8925 40:6<1772 2015 40 261 https://doi.org/10.1007/s00261-014-0345-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0345-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Paparo Francesco Unit of Radiology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut NATIONALLICENCE 700 1- Piccardo Arnoldo Nuclear Medicine Unit, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut NATIONALLICENCE 700 1- Bacigalupo Lorenzo Unit of Radiology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut NATIONALLICENCE 700 1- Romagnoli Andrea Unit of Urology, IRCCS Azienda Ospedaliera Universitaria San Martino - IST, University of Genoa, Via Leon Battista Alberti 4, 16132, Genoa, Italy aut NATIONALLICENCE 700 1- Piccazzo Riccardo Unit of Radiology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut NATIONALLICENCE 700 1- Monticone Michela Unit of Urology, IRCCS Azienda Ospedaliera Universitaria San Martino - IST, University of Genoa, Via Leon Battista Alberti 4, 16132, Genoa, Italy aut NATIONALLICENCE 700 1- Cevasco Luca Unit of Radiology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut NATIONALLICENCE 700 1- Campodonico Fabio Unit of Urology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut NATIONALLICENCE 700 1- Conzi Giuseppe Unit of Urology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut NATIONALLICENCE 700 1- Carmignani Giorgio Unit of Urology, IRCCS Azienda Ospedaliera Universitaria San Martino - IST, University of Genoa, Via Leon Battista Alberti 4, 16132, Genoa, Italy aut NATIONALLICENCE 700 1- Rollandi Gian Unit of Radiology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1772-1787 0942-8925 40:6<1772 2015 40 261