Radiogenomics of clear cell renal cell carcinoma: preliminary findings of The Cancer Genome Atlas-Renal Cell Carcinoma (TCGA-RCC) Imaging Research Group
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| 024 | 7 | 0 | |a 10.1007/s00261-015-0386-z |2 doi |
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| 245 | 0 | 0 | |a Radiogenomics of clear cell renal cell carcinoma: preliminary findings of The Cancer Genome Atlas-Renal Cell Carcinoma (TCGA-RCC) Imaging Research Group |h [Elektronische Daten] |c [Atul Shinagare, Raghu Vikram, Carl Jaffe, Oguz Akin, Justin Kirby, Erich Huang, John Freymann, Nisha I. Sainani, Cheryl Sadow, Tharakeswara Bathala, Daniel Rubin, Aytekin Oto, Matthew Heller, Venkateswar Surabhi, Venkat Katabathina, Stuart Silverman] |
| 520 | 3 | |a Purpose: To investigate associations between imaging features and mutational status of clear cell renal cell carcinoma (ccRCC). Materials and methods: This multi-institutional, multi-reader study included 103 patients (77 men; median age 59years, range 34-79) with ccRCC examined with CT in 81 patients, MRI in 19, and both CT and MRI in three; images were downloaded from The Cancer Imaging Archive, an NCI-funded project for genome-mapping and analyses. Imaging features [size (mm), margin (well-defined or ill-defined), composition (solid or cystic), necrosis (for solid tumors: 0%, 1%-33%, 34%-66% or >66%), growth pattern (endophytic, <50% exophytic, or ≥50% exophytic), and calcification (present, absent, or indeterminate)] were reviewed independently by three readers blinded to mutational data. The association of imaging features with mutational status (VHL, BAP1, PBRM1, SETD2, KDM5C, and MUC4) was assessed. Results: Median tumor size was 49mm (range 14-162mm), 73 (71%) tumors had well-defined margins, 98 (95%) tumors were solid, 95 (92%) showed presence of necrosis, 46 (45%) had ≥50% exophytic component, and 18 (19.8%) had calcification. VHL (n=52) and PBRM1 (n=24) were the most common mutations. BAP1 mutation was associated with ill-defined margin and presence of calcification (p=0.02 and 0.002, respectively, Pearson's χ 2 test); MUC4 mutation was associated with an exophytic growth pattern (p=0.002, Mann-Whitney U test). Conclusions: BAP1 mutation was associated with ill-defined tumor margins and presence of calcification; MUC4 mutation was associated with exophytic growth. Given the known prognostic implications of BAP1 and MUC4 mutations, these results support using radiogenomics to aid in prognostication and management. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Clear cell renal cell carcinoma |2 nationallicence | |
| 690 | 7 | |a CT |2 nationallicence | |
| 690 | 7 | |a MRI |2 nationallicence | |
| 690 | 7 | |a Mutational status |2 nationallicence | |
| 690 | 7 | |a Radiogenomics |2 nationallicence | |
| 700 | 1 | |a Shinagare |D Atul |u Brigham and Women's Hospital, Boston, MA, USA |4 aut | |
| 700 | 1 | |a Vikram |D Raghu |u University of Texas MD Anderson Cancer Center, Houston, TX, USA |4 aut | |
| 700 | 1 | |a Jaffe |D Carl |u Boston Medical Center, Boston, MA, USA |4 aut | |
| 700 | 1 | |a Akin |D Oguz |u Memorial Sloan Kettering Cancer Center, New York, NY, USA |4 aut | |
| 700 | 1 | |a Kirby |D Justin |u National Cancer Institute, Bethesda, USA |4 aut | |
| 700 | 1 | |a Huang |D Erich |u National Cancer Institute, Bethesda, USA |4 aut | |
| 700 | 1 | |a Freymann |D John |u National Cancer Institute, Bethesda, USA |4 aut | |
| 700 | 1 | |a Sainani |D Nisha I. |u Brigham and Women's Hospital, Boston, MA, USA |4 aut | |
| 700 | 1 | |a Sadow |D Cheryl |u Brigham and Women's Hospital, Boston, MA, USA |4 aut | |
| 700 | 1 | |a Bathala |D Tharakeswara |u University of Texas MD Anderson Cancer Center, Houston, TX, USA |4 aut | |
| 700 | 1 | |a Rubin |D Daniel |u Stanford University School of Medicine, Stanford, CA, USA |4 aut | |
| 700 | 1 | |a Oto |D Aytekin |u University of Chicago, Chicago, IL, USA |4 aut | |
| 700 | 1 | |a Heller |D Matthew |u University of Pittsburgh Medical Center, Pittsburgh, PA, USA |4 aut | |
| 700 | 1 | |a Surabhi |D Venkateswar |u University of Texas Health Science Center, Houston, TX, USA |4 aut | |
| 700 | 1 | |a Katabathina |D Venkat |u University of Texas Health Science Center, San Antonio, TX, USA |4 aut | |
| 700 | 1 | |a Silverman |D Stuart |u Brigham and Women's Hospital, Boston, MA, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1684-1692 |x 0942-8925 |q 40:6<1684 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-015-0386-z |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-015-0386-z |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shinagare |D Atul |u Brigham and Women's Hospital, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vikram |D Raghu |u University of Texas MD Anderson Cancer Center, Houston, TX, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jaffe |D Carl |u Boston Medical Center, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Akin |D Oguz |u Memorial Sloan Kettering Cancer Center, New York, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kirby |D Justin |u National Cancer Institute, Bethesda, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Huang |D Erich |u National Cancer Institute, Bethesda, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Freymann |D John |u National Cancer Institute, Bethesda, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sainani |D Nisha I. |u Brigham and Women's Hospital, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sadow |D Cheryl |u Brigham and Women's Hospital, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bathala |D Tharakeswara |u University of Texas MD Anderson Cancer Center, Houston, TX, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rubin |D Daniel |u Stanford University School of Medicine, Stanford, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Oto |D Aytekin |u University of Chicago, Chicago, IL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Heller |D Matthew |u University of Pittsburgh Medical Center, Pittsburgh, PA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Surabhi |D Venkateswar |u University of Texas Health Science Center, Houston, TX, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Katabathina |D Venkat |u University of Texas Health Science Center, San Antonio, TX, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Silverman |D Stuart |u Brigham and Women's Hospital, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1684-1692 |x 0942-8925 |q 40:6<1684 |1 2015 |2 40 |o 261 | ||