caa a22 4500 605492689 CHVBK 20210128100516.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00261-015-0386-z doi (NATIONALLICENCE)springer-10.1007/s00261-015-0386-z Radiogenomics of clear cell renal cell carcinoma: preliminary findings of The Cancer Genome Atlas-Renal Cell Carcinoma (TCGA-RCC) Imaging Research Group [Elektronische Daten] [Atul Shinagare, Raghu Vikram, Carl Jaffe, Oguz Akin, Justin Kirby, Erich Huang, John Freymann, Nisha I. Sainani, Cheryl Sadow, Tharakeswara Bathala, Daniel Rubin, Aytekin Oto, Matthew Heller, Venkateswar Surabhi, Venkat Katabathina, Stuart Silverman] Purpose: To investigate associations between imaging features and mutational status of clear cell renal cell carcinoma (ccRCC). Materials and methods: This multi-institutional, multi-reader study included 103 patients (77 men; median age 59years, range 34-79) with ccRCC examined with CT in 81 patients, MRI in 19, and both CT and MRI in three; images were downloaded from The Cancer Imaging Archive, an NCI-funded project for genome-mapping and analyses. Imaging features [size (mm), margin (well-defined or ill-defined), composition (solid or cystic), necrosis (for solid tumors: 0%, 1%-33%, 34%-66% or >66%), growth pattern (endophytic, <50% exophytic, or ≥50% exophytic), and calcification (present, absent, or indeterminate)] were reviewed independently by three readers blinded to mutational data. The association of imaging features with mutational status (VHL, BAP1, PBRM1, SETD2, KDM5C, and MUC4) was assessed. Results: Median tumor size was 49mm (range 14-162mm), 73 (71%) tumors had well-defined margins, 98 (95%) tumors were solid, 95 (92%) showed presence of necrosis, 46 (45%) had ≥50% exophytic component, and 18 (19.8%) had calcification. VHL (n=52) and PBRM1 (n=24) were the most common mutations. BAP1 mutation was associated with ill-defined margin and presence of calcification (p=0.02 and 0.002, respectively, Pearson's χ 2 test); MUC4 mutation was associated with an exophytic growth pattern (p=0.002, Mann-Whitney U test). Conclusions: BAP1 mutation was associated with ill-defined tumor margins and presence of calcification; MUC4 mutation was associated with exophytic growth. Given the known prognostic implications of BAP1 and MUC4 mutations, these results support using radiogenomics to aid in prognostication and management. Springer Science+Business Media New York, 2015 Clear cell renal cell carcinoma nationallicence CT nationallicence MRI nationallicence Mutational status nationallicence Radiogenomics nationallicence Shinagare Atul Brigham and Women's Hospital, Boston, MA, USA aut Vikram Raghu University of Texas MD Anderson Cancer Center, Houston, TX, USA aut Jaffe Carl Boston Medical Center, Boston, MA, USA aut Akin Oguz Memorial Sloan Kettering Cancer Center, New York, NY, USA aut Kirby Justin National Cancer Institute, Bethesda, USA aut Huang Erich National Cancer Institute, Bethesda, USA aut Freymann John National Cancer Institute, Bethesda, USA aut Sainani Nisha I. Brigham and Women's Hospital, Boston, MA, USA aut Sadow Cheryl Brigham and Women's Hospital, Boston, MA, USA aut Bathala Tharakeswara University of Texas MD Anderson Cancer Center, Houston, TX, USA aut Rubin Daniel Stanford University School of Medicine, Stanford, CA, USA aut Oto Aytekin University of Chicago, Chicago, IL, USA aut Heller Matthew University of Pittsburgh Medical Center, Pittsburgh, PA, USA aut Surabhi Venkateswar University of Texas Health Science Center, Houston, TX, USA aut Katabathina Venkat University of Texas Health Science Center, San Antonio, TX, USA aut Silverman Stuart Brigham and Women's Hospital, Boston, MA, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1684-1692 0942-8925 40:6<1684 2015 40 261 https://doi.org/10.1007/s00261-015-0386-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0386-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shinagare Atul Brigham and Women's Hospital, Boston, MA, USA aut NATIONALLICENCE 700 1- Vikram Raghu University of Texas MD Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Jaffe Carl Boston Medical Center, Boston, MA, USA aut NATIONALLICENCE 700 1- Akin Oguz Memorial Sloan Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- Kirby Justin National Cancer Institute, Bethesda, USA aut NATIONALLICENCE 700 1- Huang Erich National Cancer Institute, Bethesda, USA aut NATIONALLICENCE 700 1- Freymann John National Cancer Institute, Bethesda, USA aut NATIONALLICENCE 700 1- Sainani Nisha I. Brigham and Women's Hospital, Boston, MA, USA aut NATIONALLICENCE 700 1- Sadow Cheryl Brigham and Women's Hospital, Boston, MA, USA aut NATIONALLICENCE 700 1- Bathala Tharakeswara University of Texas MD Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Rubin Daniel Stanford University School of Medicine, Stanford, CA, USA aut NATIONALLICENCE 700 1- Oto Aytekin University of Chicago, Chicago, IL, USA aut NATIONALLICENCE 700 1- Heller Matthew University of Pittsburgh Medical Center, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Surabhi Venkateswar University of Texas Health Science Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Katabathina Venkat University of Texas Health Science Center, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Silverman Stuart Brigham and Women's Hospital, Boston, MA, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1684-1692 0942-8925 40:6<1684 2015 40 261