caa a22 4500 605492700 CHVBK 20210128100516.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00261-015-0391-2 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0391-2 Prediction of esophageal varices in cirrhotic patients with apparent diffusion coefficient of the spleen [Elektronische Daten] [Ahmed Razek, Samia Massoud, Mona Azziz, Mahmoud El-Bendary, Khaled Zalata, Enas Motawea] Purpose: To predict esophageal varices in cirrhotic patients with apparent diffusion coefficient (ADC) of the spleen and to correlate the ADC with clinical and laboratory biomarkers of esophageal varices. Materials and methods: This study was conducted upon 40 patients (28 male, 12 female; age ranged 19-45years; mean age=33years) with biopsy-proven cirrhotic liver. Twenty age- and sex-matched healthy volunteers were included as a control group. Patients with varices (n=15) and without varices (n=25) and volunteers underwent echo-planar diffusion-weighted MR imaging of the abdomen with b factors of 0, 400, and 800s/mm2. The ADC maps of the abdomen were reconstructed. The ADC values of the spleen were calculated and correlated with the Child score, platelet count, and prothrombin time. Results: The mean ADC value of the spleen in cirrhotic patients (1.34±0.05×10−3mm2/s) was significantly different (P=0.001) from that of volunteers (0.87±0.04×10−3mm2/s). The ADC of the spleen in cirrhotic patients with varices (1.49±0.05×10−3mm2/s) was significantly different (P=0.001) from that of patients without varices (1.11±0.06×10−3mm2/s). The cut-off ADC value of the spleen used for prediction of cirrhosis and varices was 1.15 and 1.29×10−3mm2/s with areas under the curve were 0.872 and 0.889, respectively. The ADC value of the spleen was correlated with the splenic volume (r=0.862; P=0.001), Child score (r=0.742; P=0.001), platelet count (r=-0.698; P=0.01), and prothrombin time (r=0.684; P=0.01). Conclusion: The ADC value of the spleen can predict esophageal varices in cirrhotic patients and is well correlated with the clinical and laboratory biomarkers of esophageal varices. Springer Science+Business Media New York, 2015 Diffusion nationallicence MR imaging nationallicence Cirrhosis nationallicence Varices nationallicence Razek Ahmed Department of Diagnostic Radiology, Mansoura Faculty of Medicine, 13351, Mansoura, Egypt aut Massoud Samia Department of Tropical Medicine, Al-Azhar Faculty of Medicine for Girls, Cairo, Egypt aut Azziz Mona Department of Tropical Medicine, Al-Azhar Faculty of Medicine for Girls, Cairo, Egypt aut El-Bendary Mahmoud Department of Tropical Medicine, Mansoura Faculty of Medicine, Mansoura, Egypt aut Zalata Khaled Department of Pathology, Mansoura Faculty of Medicine, Mansoura, Egypt aut Motawea Enas Department of Tropical Medicine, Al-Azhar Faculty of Medicine for Girls, Cairo, Egypt aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1465-1469 0942-8925 40:6<1465 2015 40 261 https://doi.org/10.1007/s00261-015-0391-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0391-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Razek Ahmed Department of Diagnostic Radiology, Mansoura Faculty of Medicine, 13351, Mansoura, Egypt aut NATIONALLICENCE 700 1- Massoud Samia Department of Tropical Medicine, Al-Azhar Faculty of Medicine for Girls, Cairo, Egypt aut NATIONALLICENCE 700 1- Azziz Mona Department of Tropical Medicine, Al-Azhar Faculty of Medicine for Girls, Cairo, Egypt aut NATIONALLICENCE 700 1- El-Bendary Mahmoud Department of Tropical Medicine, Mansoura Faculty of Medicine, Mansoura, Egypt aut NATIONALLICENCE 700 1- Zalata Khaled Department of Pathology, Mansoura Faculty of Medicine, Mansoura, Egypt aut NATIONALLICENCE 700 1- Motawea Enas Department of Tropical Medicine, Al-Azhar Faculty of Medicine for Girls, Cairo, Egypt aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1465-1469 0942-8925 40:6<1465 2015 40 261