caa a22 4500 605492719 CHVBK 20210128100517.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00261-015-0385-0 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0385-0 Quantification of liver, pancreas, kidney, and vertebral body MRI-PDFF in non-alcoholic fatty liver disease [Elektronische Daten] [Ilkay Idilman, Ali Tuzun, Berna Savas, Atilla Elhan, Azim Celik, Ramazan Idilman, Musturay Karcaaltincaba] Purpose: The purpose of the present study was to determine liver, pancreas, kidney, and vertebral fat deposition in NAFLD patients by proton density fat fraction (PDFF) using magnetic resonance imaging (MRI) and to evaluate the relationships among them. Methods: A total of 41 biopsy-proven NAFLD patients underwent MRI-PDFF with IDEAL-IQ. MRI protocol included T1-independent volumetric multi-echo gradient-echo imaging with T2* correction and spectral fat modeling. The MR examinations were performed on a 1.5 HDx MRI system. MRI-PDFF measurements were obtained from liver, pancreas, renal cortex and sinus, and vertebral body. Liver biopsy specimens were retrieved from the archives and evaluated by one pathologist according to NASH CRN. Results: The median age of the patients was 47years. The median interval between liver biopsy and MRI examination was 16days. Mean liver, pancreas, renal cortex, renal sinus, T12 and L1 vertebral body MRI-PDFFs were 18.7%, 5.7%, 1.7%, 51%, 43.2%, and 43.5%, respectively. No correlation between either liver MRI-PDFF or histological steatosis, and other organ MRI-PDFFs was observed. A good correlation between pancreas and vertebral body MRI-PDFFs, and pancreas and renal sinus MRI-PDFFs was observed. Diabetic patients had higher average pancreas MRI-PDFF compared to non-diabetics (12.2%, vs., 4.8%; P=0.028). Conclusions: Pancreas and vertebral body MRI-PDFF is well correlated in NAFLD patients and both of them are higher in diabetic patients which may explain increased bone fractures in diabetics. MRI-PDFF can be used to demonstrate fat fractions of different organs and tissues and to understand fat metabolism. Springer Science+Business Media New York, 2015 Non-alcoholic fatty liver disease nationallicence MRI-PDFF nationallicence Pancreas nationallicence Kidney nationallicence Vertebral body nationallicence Idilman Ilkay Department of Radiology, Faculty of Medicine, Hacettepe University, 06100, Ankara, Turkey aut Tuzun Ali Department of Gastroenterology, Faculty of Medicine, Ankara University, Ankara, Turkey aut Savas Berna Department of Pathology, Faculty of Medicine, Ankara University, Ankara, Turkey aut Elhan Atilla Department of Biostatistics, Faculty of Medicine, Ankara University, Ankara, Turkey aut Celik Azim General Electric Healthcare, Istanbul, Turkey aut Idilman Ramazan Department of Gastroenterology, Faculty of Medicine, Ankara University, Ankara, Turkey aut Karcaaltincaba Musturay Department of Radiology, Faculty of Medicine, Hacettepe University, 06100, Ankara, Turkey aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1512-1519 0942-8925 40:6<1512 2015 40 261 https://doi.org/10.1007/s00261-015-0385-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0385-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Idilman Ilkay Department of Radiology, Faculty of Medicine, Hacettepe University, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Tuzun Ali Department of Gastroenterology, Faculty of Medicine, Ankara University, Ankara, Turkey aut NATIONALLICENCE 700 1- Savas Berna Department of Pathology, Faculty of Medicine, Ankara University, Ankara, Turkey aut NATIONALLICENCE 700 1- Elhan Atilla Department of Biostatistics, Faculty of Medicine, Ankara University, Ankara, Turkey aut NATIONALLICENCE 700 1- Celik Azim General Electric Healthcare, Istanbul, Turkey aut NATIONALLICENCE 700 1- Idilman Ramazan Department of Gastroenterology, Faculty of Medicine, Ankara University, Ankara, Turkey aut NATIONALLICENCE 700 1- Karcaaltincaba Musturay Department of Radiology, Faculty of Medicine, Hacettepe University, 06100, Ankara, Turkey aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1512-1519 0942-8925 40:6<1512 2015 40 261