Simultaneous 68Ga-DOTA-TOC PET/MRI with gadoxetate disodium in patients with neuroendocrine tumor
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| 003 | CHVBK | ||
| 005 | 20210128100517.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150801xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00261-015-0409-9 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-015-0409-9 | ||
| 245 | 0 | 0 | |a Simultaneous 68Ga-DOTA-TOC PET/MRI with gadoxetate disodium in patients with neuroendocrine tumor |h [Elektronische Daten] |c [Thomas Hope, Miguel Pampaloni, Eric Nakakura, Henry VanBrocklin, James Slater, Salma Jivan, Carina Aparici, Judy Yee, Emily Bergsland] |
| 520 | 3 | |a Objective: To evaluate a simultaneous PET/MRI approach to imaging patients with neuroendocrine tumor using a combination of 68Ga-DOTA-TOC as a PET contrast agent and gadoxetate disodium as a hepatobiliary MRI contrast agent. Materials and methods: Ten patients with neuroendocrine tumor with known or suspected hepatic disease were imaged using a 68Ga-DOTA-TOC PET/CT immediately followed by a 3.0T time-of-flight PET/MRI, using a combined whole body and liver specific imaging. The presence of lesions and DOTA-TOC avidity were assessed on CT, PET from PET/CT, diffusion weighted imaging, hepatobiliary phase imaging (HBP), and PET from PET/MRI. Maximum standardized uptake values (SUVmax) in hepatic lesions and nodal metastases were compared between PET/CT and PET/MRI, as were detection rates using each imaging approach. Results: A total of 101 hepatic lesions were identified, 47 of which were DOTA-TOC avid and able to be individually measured on both PET/CT and PET/MRI. HBP imaging had a higher sensitivity for detection of hepatic lesions compared to CT or PET (99% vs. 46% and 64%, respectively; p values <0.001). There was a strong correlation between SUVmax of liver lesions obtained with PET/CT compared to PET/MR imaging (Pearson's correlation=0.91). For nodal disease, CT had a higher sensitivity compared to whole body MRI (p=0.015), although PET acquired from PET/MRI detected slightly more lesions compared to PET from PET/CT. Conclusions: A simultaneous PET/MRI using both 68Ga-DOTA-TOC and gadoxetate disodium was successful in whole body staging of patients with neuroendocrine tumor. HBP imaging had an increased detection rate for hepatic metastases. | |
| 540 | |a Springer Science+Business Media New York (outside the USA), 2015 | ||
| 690 | 7 | |a Neuroendocrine tumor |2 nationallicence | |
| 690 | 7 | |a Hepatobiliary agents |2 nationallicence | |
| 690 | 7 | |a PET/MRI |2 nationallicence | |
| 690 | 7 | |a Ga-68 DOTA-TOC |2 nationallicence | |
| 700 | 1 | |a Hope |D Thomas |u Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA |4 aut | |
| 700 | 1 | |a Pampaloni |D Miguel |u Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA |4 aut | |
| 700 | 1 | |a Nakakura |D Eric |u Division of Surgical Oncology, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA |4 aut | |
| 700 | 1 | |a VanBrocklin |D Henry |u Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA |4 aut | |
| 700 | 1 | |a Slater |D James |u Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA |4 aut | |
| 700 | 1 | |a Jivan |D Salma |u Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA |4 aut | |
| 700 | 1 | |a Aparici |D Carina |u Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA |4 aut | |
| 700 | 1 | |a Yee |D Judy |u Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA |4 aut | |
| 700 | 1 | |a Bergsland |D Emily |u Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1432-1440 |x 0942-8925 |q 40:6<1432 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-015-0409-9 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-015-0409-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hope |D Thomas |u Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pampaloni |D Miguel |u Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nakakura |D Eric |u Division of Surgical Oncology, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a VanBrocklin |D Henry |u Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Slater |D James |u Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jivan |D Salma |u Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Aparici |D Carina |u Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yee |D Judy |u Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bergsland |D Emily |u Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1432-1440 |x 0942-8925 |q 40:6<1432 |1 2015 |2 40 |o 261 | ||