caa a22 4500 605492735 CHVBK 20210128100517.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00261-015-0409-9 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0409-9 Simultaneous 68Ga-DOTA-TOC PET/MRI with gadoxetate disodium in patients with neuroendocrine tumor [Elektronische Daten] [Thomas Hope, Miguel Pampaloni, Eric Nakakura, Henry VanBrocklin, James Slater, Salma Jivan, Carina Aparici, Judy Yee, Emily Bergsland] Objective: To evaluate a simultaneous PET/MRI approach to imaging patients with neuroendocrine tumor using a combination of 68Ga-DOTA-TOC as a PET contrast agent and gadoxetate disodium as a hepatobiliary MRI contrast agent. Materials and methods: Ten patients with neuroendocrine tumor with known or suspected hepatic disease were imaged using a 68Ga-DOTA-TOC PET/CT immediately followed by a 3.0T time-of-flight PET/MRI, using a combined whole body and liver specific imaging. The presence of lesions and DOTA-TOC avidity were assessed on CT, PET from PET/CT, diffusion weighted imaging, hepatobiliary phase imaging (HBP), and PET from PET/MRI. Maximum standardized uptake values (SUVmax) in hepatic lesions and nodal metastases were compared between PET/CT and PET/MRI, as were detection rates using each imaging approach. Results: A total of 101 hepatic lesions were identified, 47 of which were DOTA-TOC avid and able to be individually measured on both PET/CT and PET/MRI. HBP imaging had a higher sensitivity for detection of hepatic lesions compared to CT or PET (99% vs. 46% and 64%, respectively; p values <0.001). There was a strong correlation between SUVmax of liver lesions obtained with PET/CT compared to PET/MR imaging (Pearson's correlation=0.91). For nodal disease, CT had a higher sensitivity compared to whole body MRI (p=0.015), although PET acquired from PET/MRI detected slightly more lesions compared to PET from PET/CT. Conclusions: A simultaneous PET/MRI using both 68Ga-DOTA-TOC and gadoxetate disodium was successful in whole body staging of patients with neuroendocrine tumor. HBP imaging had an increased detection rate for hepatic metastases. Springer Science+Business Media New York (outside the USA), 2015 Neuroendocrine tumor nationallicence Hepatobiliary agents nationallicence PET/MRI nationallicence Ga-68 DOTA-TOC nationallicence Hope Thomas Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA aut Pampaloni Miguel Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA aut Nakakura Eric Division of Surgical Oncology, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA aut VanBrocklin Henry Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA aut Slater James Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA aut Jivan Salma Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA aut Aparici Carina Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA aut Yee Judy Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA aut Bergsland Emily Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1432-1440 0942-8925 40:6<1432 2015 40 261 https://doi.org/10.1007/s00261-015-0409-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0409-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hope Thomas Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Pampaloni Miguel Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Nakakura Eric Division of Surgical Oncology, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA aut NATIONALLICENCE 700 1- VanBrocklin Henry Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Slater James Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Jivan Salma Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Aparici Carina Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Yee Judy Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue - 0628, 94143-0628, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Bergsland Emily Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1432-1440 0942-8925 40:6<1432 2015 40 261