caa a22 4500 605492751 CHVBK 20210128100517.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00261-014-0333-4 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0333-4 Influence of the adaptive iterative dose reduction 3D algorithm on the detectability of low-contrast lesions and radiation dose repeatability in abdominal computed tomography: a phantom study [Elektronische Daten] [Jeong Yoon, Jeong Lee, Bo Hur, Jeehyun Baek, Hackjoon Shim, Joon Han, Byung Choi] Purpose: The purpose of the study is to evaluate the influence of the adaptive iterative dose reduction (AIDR 3D) algorithm on the detectability of low-contrast focal liver lesions (FLLs) and the radiation dose repeatability of automatic tube current modulation (ATCM) in abdominal CT scans using anthropomorphic phantoms. Materials and Methods: Three different sizes of anthropomorphic phantoms, each with 4 low-contrast FLLs, were scanned on a 320-channel CT scanner using the ATCM technique and AIDR 3D, at different radiation doses: full-dose, half-dose, and quarter-dose. Scans were repeated three times and reconstructed with filtered back projection (FBP) and AIDR 3D. Radiation dose repeatability was assessed using the intraclass correlation coefficient (ICC). Image noise, quality, and lesion conspicuity were assessed by four reviewers and the number of invisible FLLs was compared among different radiation doses and reconstruction methods. Results: ICCs of radiation dose among the three CT scans were excellent in all phantoms (0.99). Image noise, quality, and lesion conspicuity in the half-dose group were comparable with full-dose FBP after applying AIDR 3D in all phantoms. In small phantoms, the half-dose group reconstructed with AIDR 3D showed similar sensitivity in visualizing low-contrast FLLs compared to full-dose FBP (P=0.77-0.84). In medium and large phantoms, AIDR 3D reduced the number of missing low-contrast FLLs [3.1% (9/288), 11.5% (33/288), respectively], compared to FBP [10.4% (30/288), 21.9% (63/288), respectively] in the full-dose group. Conclusion: By applying AIDR 3D, half-dose CT scans may be achievable in small-sized patients without hampering diagnostic performance, while it may improve diagnostic performance in medium- and large-sized patients without increasing the radiation dose. Springer Science+Business Media New York, 2014 Iterative reconstruction nationallicence AIDR 3D nationallicence Low-contrast detectability nationallicence Body size nationallicence Computed tomography nationallicence Yoon Jeong Department of Radiology, Seoul National University Hospital, Seoul, Korea aut Lee Jeong Department of Radiology, Seoul National University Hospital, Seoul, Korea aut Hur Bo Department of Radiology, SMG-SNU Boramae Medical Center, Seoul, Korea aut Baek Jeehyun Human Medical Imaging & Intervention Center, Seoul, Korea aut Shim Hackjoon Toshiba Medical Systems Korea Co. Ltd, Seoul, Korea aut Han Joon Department of Radiology, Seoul National University Hospital, Seoul, Korea aut Choi Byung Department of Radiology, Seoul National University Hospital, Seoul, Korea aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1843-1852 0942-8925 40:6<1843 2015 40 261 https://doi.org/10.1007/s00261-014-0333-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0333-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoon Jeong Department of Radiology, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Jeong Department of Radiology, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Hur Bo Department of Radiology, SMG-SNU Boramae Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Baek Jeehyun Human Medical Imaging & Intervention Center, Seoul, Korea aut NATIONALLICENCE 700 1- Shim Hackjoon Toshiba Medical Systems Korea Co. Ltd, Seoul, Korea aut NATIONALLICENCE 700 1- Han Joon Department of Radiology, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Choi Byung Department of Radiology, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1843-1852 0942-8925 40:6<1843 2015 40 261