caa a22 4500 605492794 CHVBK 20210128100517.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00261-014-0291-x doi (NATIONALLICENCE)springer-10.1007/s00261-014-0291-x Diagnostic performances of FDG-PET/CT and diffusion-weighted imaging indices for differentiating benign pheochromocytoma from other benign adrenal tumors [Elektronische Daten] [Masatoyo Nakajo, Masayuki Nakajo, Yoshihiko Fukukura, Megumi Jinguji, Toshikazu Shindo, Yoshiaki Nakabeppu, Kiyohisa Kamimura, Tomohide Yoneyama, Koji Takumi, Takashi Yoshiura] Purpose: The purpose of this study is to compare diagnostic performances of 18F-fluorodeoxyglucose (FDG) visual score, maximum standardized uptake value (SUVmax), ratio of adrenal SUVmax to liver SUVmax (A/L SUVmax), apparent diffusion coefficient (ADC) from diffusion-weighted imaging, and SUVmax/ADC ratio to differentiate adrenal pheochromocytoma from other benign tumors. Methods: Eleven pheochromocytomas and 22 other benign tumors in 30 patients were included. FDG-based indices, ADC, and SUVmax/ADC ratio were compared between groups using the Mann-Whitney U test, and sensitivity, specificity, accuracy, and area under the curve (AUC) for diagnosing pheochromocytoma by receiver operating characteristic analyses. The correlation between SUVmax and ADC was analyzed using the Spearman's rank test. Results: Pheochromocytoma showed significantly higher visual score (2.8±0.4 vs. 1.3±0.9), SUVmax (11.0±8.9 vs. 3.2±1.4), A/L SUVmax ratio (3.96±3.48 vs. 0.96±0.51), and SUVmax/ADC ratio (10.6±8.09 vs. 2.28±0.98) (each P<0.001) and significantly lower ADC (1.08±0.23×10−3mm2/s vs. 1.43±0.29×10−3 mm2/s, P=0.003) than other benign tumors. Sensitivity, specificity, and accuracy for diagnosing pheochromocytoma were 100, 73, and 82% for visual score, 100, 86, and 91% for both SUVmax and A/L SUVmax ratio, and 64, 100, and 88% for ADC and 82, 95, and 91% for SUVmax/ADC ratio. No significant differences in AUC were found between FDG-based indices, ADC, and SUVmax/ADC ratio. A significant negative correlation was noted between SUVmax and ADC (ρ=−0.36, P=0.039). Conclusion: FDG-based indices and ADC appear comparably useful for differentiating pheochromocytoma from other benign adrenal tumors. Springer Science+Business Media New York, 2014 Adrenal tumor nationallicence Pheochromocytoma nationallicence FDG nationallicence SUV nationallicence ADC nationallicence Nakajo Masatoyo Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut Nakajo Masayuki Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut Fukukura Yoshihiko Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut Jinguji Megumi Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut Shindo Toshikazu Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut Nakabeppu Yoshiaki Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut Kamimura Kiyohisa Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut Yoneyama Tomohide Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut Takumi Koji Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut Yoshiura Takashi Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1655-1665 0942-8925 40:6<1655 2015 40 261 https://doi.org/10.1007/s00261-014-0291-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0291-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakajo Masatoyo Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 700 1- Nakajo Masayuki Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 700 1- Fukukura Yoshihiko Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 700 1- Jinguji Megumi Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 700 1- Shindo Toshikazu Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 700 1- Nakabeppu Yoshiaki Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 700 1- Kamimura Kiyohisa Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 700 1- Yoneyama Tomohide Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 700 1- Takumi Koji Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 700 1- Yoshiura Takashi Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1655-1665 0942-8925 40:6<1655 2015 40 261