Comparison of hybrid FDG PET/MRI compared with PET/CT in colorectal cancer staging and restaging: a pilot study
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| 024 | 7 | 0 | |a 10.1007/s00261-015-0474-0 |2 doi |
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| 245 | 0 | 0 | |a Comparison of hybrid FDG PET/MRI compared with PET/CT in colorectal cancer staging and restaging: a pilot study |h [Elektronische Daten] |c [Raj Paspulati, Sasan Partovi, Karin Herrmann, Smitha Krishnamurthi, Conor Delaney, Nghi Nguyen] |
| 520 | 3 | |a Purpose: We report our initial clinical experience from a pilot study to compare the diagnostic accuracy of hybrid PET/MRI with PET/CT in colorectal cancer and discuss potential PET/MRI workflow solutions for colorectal cancer. Methods: Patients underwent both FDG PET/CT and PET/MRI (Ingenuity TF PET/MRI, Philips Healthcare) for rectal cancer staging or colorectal cancer restaging. The PET acquisition of PET/MRI was similar to that of PET/CT whereas the MRI protocol was selected individually based on the patient's medical history. One nuclear medicine physician reviewed the PET/CT studies and one radiologist reviewed the PET/MRI studies independently. The diagnostic accuracy of each modality was determined in consensus, using available medical records as a reference. Results: Of the 12 patients enrolled, two were for initial staging and ten for restaging. The median scan delay between the two modalities was 60 min. The initial imaging was PET/CT in nine patients and PET/MRI in three patients. When PET/CT was performed first, the SUV values of the 16 FDG avid lesions were greater at PET/MRI than at PET/CT. In contrast, when PET/MRI was performed first, the SUV values of the seven FDG avid lesions were greater at PET/CT than at PET/MRI. PET/MRI provided more detailed T staging than PET/CT. On a per-patient basis, with both patient groups combined for the evaluation of N and M staging/restaging, the true positive rate was 5/7 (71%) for PET/CT and 6/7 (86%) for PET/MRI, and true negative rate was 5/5 (100%) for both modalities. On a per-lesion basis, PET/CT identified 26 of 29 (90%) tumor lesions that were correctly detected by PET/MRI. Our proposed workflow allows for comprehensive cancer staging including integrated local and whole-body assessment. Conclusions: Our initial experience shows a high diagnostic accuracy of PET/MRI in T staging of rectal cancer compared with PET/CT. In addition, PET/MRI shows at least comparable accuracy in N and M staging as well as restaging to PET/CT. However, the small sample size limits the generalizability of the results. It is expected that PET/MRI would yield higher diagnostic accuracy than PET/CT considering the high soft tissue contrast provided by MRI compared with CT, but larger studies are necessary to fully assess the benefit of PET/MRI in colorectal cancer. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a PET/MR |2 nationallicence | |
| 690 | 7 | |a PET/CT |2 nationallicence | |
| 690 | 7 | |a Rectal carcinoma |2 nationallicence | |
| 690 | 7 | |a Liver metastases |2 nationallicence | |
| 700 | 1 | |a Paspulati |D Raj |u Department of Radiology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA |4 aut | |
| 700 | 1 | |a Partovi |D Sasan |u Department of Radiology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA |4 aut | |
| 700 | 1 | |a Herrmann |D Karin |u Department of Radiology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA |4 aut | |
| 700 | 1 | |a Krishnamurthi |D Smitha |u Department of Medicine-Hematology and Oncology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA |4 aut | |
| 700 | 1 | |a Delaney |D Conor |u Department of Surgery-Colorectal, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA |4 aut | |
| 700 | 1 | |a Nguyen |D Nghi |u Radiology Department, UPMC Presbyterian, 200 Lothrop St, 15213, Pittsburgh, PA, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1415-1425 |x 0942-8925 |q 40:6<1415 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-015-0474-0 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-015-0474-0 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Paspulati |D Raj |u Department of Radiology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Partovi |D Sasan |u Department of Radiology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Herrmann |D Karin |u Department of Radiology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Krishnamurthi |D Smitha |u Department of Medicine-Hematology and Oncology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Delaney |D Conor |u Department of Surgery-Colorectal, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nguyen |D Nghi |u Radiology Department, UPMC Presbyterian, 200 Lothrop St, 15213, Pittsburgh, PA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1415-1425 |x 0942-8925 |q 40:6<1415 |1 2015 |2 40 |o 261 | ||