caa a22 4500 605492832 CHVBK 20210128100517.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00261-015-0474-0 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0474-0 Comparison of hybrid FDG PET/MRI compared with PET/CT in colorectal cancer staging and restaging: a pilot study [Elektronische Daten] [Raj Paspulati, Sasan Partovi, Karin Herrmann, Smitha Krishnamurthi, Conor Delaney, Nghi Nguyen] Purpose: We report our initial clinical experience from a pilot study to compare the diagnostic accuracy of hybrid PET/MRI with PET/CT in colorectal cancer and discuss potential PET/MRI workflow solutions for colorectal cancer. Methods: Patients underwent both FDG PET/CT and PET/MRI (Ingenuity TF PET/MRI, Philips Healthcare) for rectal cancer staging or colorectal cancer restaging. The PET acquisition of PET/MRI was similar to that of PET/CT whereas the MRI protocol was selected individually based on the patient's medical history. One nuclear medicine physician reviewed the PET/CT studies and one radiologist reviewed the PET/MRI studies independently. The diagnostic accuracy of each modality was determined in consensus, using available medical records as a reference. Results: Of the 12 patients enrolled, two were for initial staging and ten for restaging. The median scan delay between the two modalities was 60 min. The initial imaging was PET/CT in nine patients and PET/MRI in three patients. When PET/CT was performed first, the SUV values of the 16 FDG avid lesions were greater at PET/MRI than at PET/CT. In contrast, when PET/MRI was performed first, the SUV values of the seven FDG avid lesions were greater at PET/CT than at PET/MRI. PET/MRI provided more detailed T staging than PET/CT. On a per-patient basis, with both patient groups combined for the evaluation of N and M staging/restaging, the true positive rate was 5/7 (71%) for PET/CT and 6/7 (86%) for PET/MRI, and true negative rate was 5/5 (100%) for both modalities. On a per-lesion basis, PET/CT identified 26 of 29 (90%) tumor lesions that were correctly detected by PET/MRI. Our proposed workflow allows for comprehensive cancer staging including integrated local and whole-body assessment. Conclusions: Our initial experience shows a high diagnostic accuracy of PET/MRI in T staging of rectal cancer compared with PET/CT. In addition, PET/MRI shows at least comparable accuracy in N and M staging as well as restaging to PET/CT. However, the small sample size limits the generalizability of the results. It is expected that PET/MRI would yield higher diagnostic accuracy than PET/CT considering the high soft tissue contrast provided by MRI compared with CT, but larger studies are necessary to fully assess the benefit of PET/MRI in colorectal cancer. Springer Science+Business Media New York, 2015 PET/MR nationallicence PET/CT nationallicence Rectal carcinoma nationallicence Liver metastases nationallicence Paspulati Raj Department of Radiology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA aut Partovi Sasan Department of Radiology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA aut Herrmann Karin Department of Radiology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA aut Krishnamurthi Smitha Department of Medicine-Hematology and Oncology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA aut Delaney Conor Department of Surgery-Colorectal, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA aut Nguyen Nghi Radiology Department, UPMC Presbyterian, 200 Lothrop St, 15213, Pittsburgh, PA, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1415-1425 0942-8925 40:6<1415 2015 40 261 https://doi.org/10.1007/s00261-015-0474-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0474-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Paspulati Raj Department of Radiology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Partovi Sasan Department of Radiology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Herrmann Karin Department of Radiology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Krishnamurthi Smitha Department of Medicine-Hematology and Oncology, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Delaney Conor Department of Surgery-Colorectal, UH Case Medical Center, 11100 Euclid Ave, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Nguyen Nghi Radiology Department, UPMC Presbyterian, 200 Lothrop St, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1415-1425 0942-8925 40:6<1415 2015 40 261